Conjunctival MALToma Patient with Intraocular Manifestation: A Case Report.

Suh, Min Hee; Kim, Ji Hoon; Yu, Hyeong Gon

Case Report

Journal of the Korean Ophthalmological Society 2007;48(3):460-464.
Published online March 31, 2007.

Conjunctival MALToma Patient with Intraocular Manifestation: A Case Report.

¹Department of Ophthalmology, Seoul National University College of Medicine, Seoul, Korea. hgonyu@snu.ac.kr
²Seoul Artificial Eye Center, Seoul National University Hospital Clinical Research Institute, Seoul, Korea.
³Department of Pathology, Seoul National University College of Medicine, Seoul, Korea.

결막의 점막연관 림프조직형 림프종(MALToma)의 안구 내 침범 환자 1례 보고

서민희¹,김지훈³,유형곤^1,2

Department of Ophthalmology, Seoul National University College of Medicine¹, Seoul, Korea Seoul Artificial Eye Center, Seoul National University Hospital Clinical Research Institute², Seoul, Korea Department of Pathology, Seoul National University College of Medicine³, Seoul, Korea

Correspondence: Min Hee Suh, M.D.¹

Abstract

PURPOSE
To report one case of unilateral intraocular involvement of the MALToma (Mucosa Associated Lymphoid Tissue Lymphoma) in the patient with bilateral conjunctival MALToma which was cured by radiation therapy 8 years ago. METHODS: A 64 year old woman who was in remission status after radiation therapy of the bilateral conjunctival MALToma presented with vitreous opacity, inflammatory reaction in anterior chamber, iris posterior synechiae and keratic precipitate in her left eye. Visual acuity of her left eye decreased from 20/33 to 20/100. Pars planar vitrectomy and cytologic analysis of the vitreous sample were performed. RESULTS: Cytologic analysis of the vitreous sample showed atypical lymphoid cells containing vacuolar nuclei which were stained positive at CD20 marker in the immunohistochemistry. So radiation therapy of the left eye was performed in the diagnosis of intraocular involvement of the MALToma. CONCLUSIONS: If severe panuveitis occurs in the patient with radiation therapy of the conjunctival MALToma, intraocular involvement of the MALToma should be considered as one of the differential diagnosis.

Key Words: MALToma;Conjunctiva;Panuveitis;Intraocular involvement