Journal of the Korean Ophthalmological Society 2007;48(6):749-754.
Published online June 30, 2007.
Therapeutic Effect of Botulinum Toxin Injection in Eyelid Myokymia Patients.
Su Byung Yu, Helen Lew, Young Soo Yun
Department of Ophthalmology, Pochun CHA University College of Medicine, Pundang CHA Hospital, Sungnam, Korea. eye@cha.ac.kr
안윤근파동 환자에서 보툴리눔 독소의 치료 효과
유수병,유혜린,윤영수
Department of Ophthalmology, Pochun CHA University College of Medicine, Pundang CHA Hospital, Sungnam, Korea
Correspondence:  Su Byung Yu, M.D.
Abstract
PURPOSE
To evaluate clinical manifestations and effects of botulinum toxin in eyelid myokymia patients. METHODS: Between March 2001 and March 2005, botulinum toxin injection therapy was performed in 12 eyelid myokymia patients. We evaluated duration of disease, systemic disease, drug history, and range, grade, frequency of myokymia at the first visit. Botulinum injections were performed in patients with normal results of blood tests and neuroimaging tests. Improvement of symptoms, duration of effectiveness, and complications were evaluated after the botulinum toxin injection therapies. Data was analyzed with the Mann-Whitney U test. RESULTS: Improvement of symptoms was noticed in 10 patients (83.3%). Among the 10 patients, 5 patients were decided as cured patients because they did not require any retreatment. Range and grade of myokymia didn't affect on effect of treatment. Pain, edema, excessive tearing, and unnatural face were noticed as complications of treatment, but all complications disappeared 2 weeks after the treatment. CONCLUSIONS: Botulinum toxin injection therapy is noninvasive and effective treatment in benign eyelid myokymia patients without causal neurologic disease.
Key Words: Botulinum toxin;Myokymia


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