The Efficacy of Amniotic Membrane Graft in the Treatment of Symptomatic Bullous Keratopathy. |
Jung Hyun Park, Jin Wook Jeoung, Won Ryang Wee, Jin Hak Lee, Mee Kum Kim, Jae Lim Lee |
1Department of Ophthalmology, Seoul National University College of Medicine, Seoul, Korea. kmk9@snu.ac.kr 2Seoul Artificial Eye Center, Clinical Research Institute, Seoul National University Hospital, Seoul, Korea. 3Valued Eye Clinic, Seoul, Korea. |
수포각막병증에서 양막 이식술의 효용성 |
박정현1,정진욱1,위원량1,2,이진학1,2,김미금1,2,이재림3 |
Department of Ophthalmology, Seoul National University College of Medicine1, Seoul, Korea Seoul Artificial Eye Center, Clinical Research Institute, Seoul National University Hospital2, Seoul, Korea Valued Eye Clinic3, Seoul, Korea |
Correspondence:
Mee Kum Kim, M.D. |
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Abstract |
PURPOSE To evaluate the efficacy of amniotic membrane (AM) transplantation in symptomatic bullous keratopathy using cryo-preserved or lyophilized AM. METHODS: Eight bullous keratopathic patients, who experienced intractable pain despite medication and the application of a therapeutic lens, underwent permanent AM transplantation with 5 cryo-preserved and 3 lyophilized AMs following removal of epithelium using a trephine. The time to re-epithelization and the subsidence of pain were evaluated retrospectively. RESULTS: Mean follow-up was 252+/-171.0 days. Pain relief and re-epithelization were obtained in all eight patients. The times to complete relief of pain was 32.2+/-22.7 days in patients with cryo-preserved AM transplantations (n=5) and 22.0+/-18.0 days in those with lyophilized AM transplantations (n=3) (p=0.549, Mann-Whitney U test). Respective times to re-epithelization were 25.4+/-20.7 days and 23.0+/-25.2 days (p=0.297). There were no significant differences in the diameter of transplanted AMs between the two groups (7.6+/-0.2 vs. 7.3+/-0.3 mm, p=0.172). CONCLUSIONS: Permanent AM transplantation effectively reduced the intractable pain caused by epithelial bulla. Whether the AM was cryo-preserved or lyophilized did not affect the efficacy of the treatment. |
Key Words:
Amniotic membrane transplantation;Bullous keratophathy;Epithelization;Preservation |
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