Clinical Course of Bimatoprost-induced Periocular Skin Hyperpigmentation after Stopping Bimatoprost Treatment.

Lee, Dong Wook

doi:2007.48.8.1082

J Korean Ophthalmol Soc > Volume 48(8); 2007 > Article

Original Article

Journal of the Korean Ophthalmological Society 2007;48(8):1082-1087.
DOI: https://doi.org/10.3341/jkos.2007.48.8.1082-1087 Published online August 31, 2007.

Clinical Course of Bimatoprost-induced Periocular Skin Hyperpigmentation after Stopping Bimatoprost Treatment.

Dong Wook Lee

Department of Ophthalmology, Chonbuk National University, Medical School, Jeonju, Korea. ldw@chonbuk.ac.kr

비마토프로스트 점안 후 눈 주변 피부 색소침착이 발생한 환자에서 약물중단 후 경과

이동욱

Department of Ophthalmology, Chonbuk National University, Medical School, Jeonju, Korea

Correspondence: Dong Wook Lee, M.D.

Abstract

PURPOSE
To evaluate the demographic and clinical characteristics of bimatoprost-induced periocular skin hyperpigmentation. METHODS: The chart analyses of 16 patients in whom cosmetically noticeable periocular skin hyperpigmentation developed after starting bimatoprost therapy were reviewed. Data collated included age, medication history, dates of starting and stopping bimatoprost treatment, and the subjective assessment of the periocular hyperpigmentation at initial detection as well as follow-up visits. Periocular hyperpigmentation was graded using an arbitrary scale from 0 to 3. The number of days to the onset of hyperpigmentation and to pigment resolution was determined and their associations to demographic and other clinical parameters were analyzed. RESULTS: Patients had variable grades of periocular hyperpigmentation at presentation (mean, 1.53+/-0.66). Bimatoprost-induced periocular hyperpigmentation appeared 1-10 (mean, 4.3+/-2.6) months after initiation of bimatoprost therapy. Resolution of skin hyperpigmentation was noted 2-10(mean 6.8+/-1.9) months after stopping bimatoprost treatment. There was a minor correlation(R=+0.19) between the number of days to resolution of hyperpigmentation and the number of days when bimatoprost was used. At 12 months after stopping bimatoprost treatment, 12 of the 13 patients had complete resolution of periocular hyperpigmentation. However, weak hyperpigmentation remained in one patient. CONCLUSIONS: Bimatoprost-induced hyperpigmentation is benign and reversible.

Key Words: Bimatoprost;Hyperpigmentation