J Korean Ophthalmol Soc > Volume 48(9); 2007 > Article
Journal of the Korean Ophthalmological Society 2007;48(9):1234-1241.
DOI: https://doi.org/10.3341/jkos.2007.48.9.1234    Published online September 30, 2007.
The Clinical Courses of Retinoblastoma Patients Who Underwent Bilateral Enucleation.
Sang Beom Han, Jeong Hun Kim, Ho Kyung Choung, Seong Joon Kim, Sang In Khwarg, Young Suk Yu
1Department of Ophthalmology, Seoul National University College of Medicine, Seoul, Korea. ysyu@snu.ac.kr
2Seoul Artificial Eye Center, Seoul National University Hospital Clinical Research Institute, Seoul, Korea.
3Department of Ophthalmology, Seoul Metropolitanl Boramae Hospital, Seoul, Korea.
양안 안구적출술을 받은 망막모세포종 환아들의 임상경과
한상범1,김정훈1,정호경1,2,3,김성준1,2,곽상인1,2,유영석1,2
Department of Ophthalmology, Seoul National University College of Medicine1, Seoul, Korea Seoul Artificial Eye Center, Seoul National University Hospital Clinical Research Institute2, Seoul, Korea Department of Ophthalmology, Seoul Metropolitanl Boramae Hospital3, Seoul, Korea
Correspondence:  Young Suk Yu, M.D.
Abstract
PURPOSE
To investigate the courses leading to bilateral enucleation in bilateral retinoblastoma patients. METHODS: Medical records of 5 bilateral retinoblastoma patients who underwent bilateral enucleation were reviewed for patient information, history, change of tumor state during the treatment and the cause of bilateral enucleation. RESULTS: Out of 48 bilateral retinoblastoma patients, both eyes were saved in 6 children, 1 eye was saved in 37 children, and the remaining 5 children lost both eyes. All patients who underwent bilateral enucleation were female and had no family history of retinoblastoma. At diagnosis, 3 children were 4 months old and the remaining 2 patients were 1 year and 1.5 years old each. Out of 10 eyes, 8 eyes were in Reese Ellsworth group V and the remaining 2 eyes were in group III. The initial treatment was enucleation of 1 eye followed by chemotherapy in 3 patients, and chemotherapy alone in 2 patients. Additional treatment included laser photocoagulation, cryotherapy, external beam radiation therapy and proton beam irradiation. Vitreous seeding, development of new tumors, and increase in tumor size despite of intensive, conservative treatment resulted in second enucleation. CONSLUSION: Most patients who underwent bilateral enucleation were 1 year old or younger at diagnosis of retinoblastoma. All patients had a progressed disease status at presentation and showed poor response to intensive, conservative treatment.
Key Words: Retinoblastoma;Enucleation;Bilateral retinoblastoma;Bilateral enucleation


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