Analysis of Risk Factors for Treatment Failure in Fungal Keratitis.

Lee, Kwang Hoon; Chae, Hong Jae; Yoon, Kyung Chul

doi:2008.49.5.737

J Korean Ophthalmol Soc > Volume 49(5); 2008 > Article

Original Article

Journal of the Korean Ophthalmological Society 2008;49(5):737-742.
DOI: https://doi.org/10.3341/jkos.2008.49.5.737 Published online May 15, 2008.

Analysis of Risk Factors for Treatment Failure in Fungal Keratitis.

Kwang Hoon Lee, Hong Jae Chae, Kyung Chul Yoon

¹Department of Ophthalmology, Chonnam National University Medical School & Hospital, Gwangju, Korea. cyoon@chonnam.ac.kr
²Department of Occupational Environment Medicine, Chonnam National University Medical School & Hospital, Gwangju, Korea.

진균각막염에서 치료실패의 위험인자에 대한 분석

이광훈¹ㆍ채홍재²ㆍ윤경철¹

Department of Ophthalmology1 and Occupational Environment Medicine2, Chonnam National University Medical School & Hospital, Gwangju, Korea

Abstract

PURPOSE
To evaluate the risk factors for treatment failure in fungal keratits. METHODS: A total of 109 patients with fungal keratitis, who were diagnosed by clinical findings, smears, and cultures and followed up for at least 2 months, were studied retrospectively. Age, sex, previous history of trauma, systemic diseases, corticosteroid use, previous ocular disease, features of keratitis, causative organism, and treatment results were reviewed. An initial univariate and multivariate logistic regression analysis was performed to identify and select the main prognostic risk factors. RESULTS: Treatment was successful in 76 patients (69.7%) and failed in 33 patients (30.3%). Fusarium species was isolated in 34 eyes (40.0%), and an ulcer lesion was located in the central area of 54 eyes (49.5%). Multivariate analysis demonstrated that predictors of treatment failure were an ulcer exceeding 10 mm2 (P<0.001) and the presence of previous ocular diseases (P=0.007). CONCLUSIONS: In patients with fungal keratitis, a large ulcer size and the presence of other ocular diseases were risk factors for treatment failure.

Key Words: Fungal keratitis;Risk factor;Treatment failure