Effect of Needle Revision of Failed Filtering Blebs with Different Concentrations of Mitomycin C.

Woo, Kyeong Jin; Hyung, Sungmin

doi:2008.49.6.951

J Korean Ophthalmol Soc > Volume 49(6); 2008 > Article

Original Article

Journal of the Korean Ophthalmological Society 2008;49(6):951-957.
DOI: https://doi.org/10.3341/jkos.2008.49.6.951 Published online June 15, 2008.

Effect of Needle Revision of Failed Filtering Blebs with Different Concentrations of Mitomycin C.

Kyeong Jin Woo, Sungmin Hyung

Department of Ophthalmology, School of Medicine, Chungbuk National University, Chungbuk, Korea. smh@chungbuk.ac.kr

섬유주절제술 후 여과포형성에 실패한 환자에서 마이토마이신씨 농도에 따른 주사침복원술의 효과

우경진ㆍ형성민

Department of Ophthalmology, School of Medicine, Chungbuk National University, Chungbuk, Korea

Abstract

PURPOSE
To investigate the efficacy and the risk factors for failure and complications of mitomycin C (MMC)-augmented needle revision (NR) of failed filtering blebs. METHODS: Thirty eyes whose intraocular pressure (IOP) did not decrease after the cutting of scleral flap sutures were recruited. NR was performed with a 26-gauge needle under a slit-lamp. Immediately following NR, all eyes received a subconjunctival injection of 0.1 ml of 0.02 mg/ml (group A) or 0.1 mg/ml (group B) MMC at the adjacent conjunctiva. The mean follow-up period after the last needle revision was 13.2+/-4.2 months. RESULTS: The mean IOP decreased from 25.7+/-10.6 mmHg before surgery to 13.7+/-2.5 mmHg at the last follow-up in group A and from 24.1+/-6.8 mmHg to 17.7+/-8.6 mmHg in group B (group A: p=0.001, group B: p=0.065). Subconjunctival hemorrhage, hyphema, and a shallow anterior chamber appeared in most cases. However, choridal detachment and avascular changes of the conjunctiva were observed in group B. CONCLUSIONS: IOP decreased in both groups A and B, but severe complications appeared only in group B. NR followed by a subconjunctival injection of 0.02 rather than 0.1 mg/ml is a safe and effective method.

Key Words: Filtering bleb;Mitomycin C;Needle revision