J Korean Ophthalmol Soc > Volume 49(7); 2008 > Article
Journal of the Korean Ophthalmological Society 2008;49(7):1154-1158.
DOI: https://doi.org/10.3341/jkos.2008.49.7.1154    Published online July 15, 2008.
Effects of Intravitreal Amniotic Membrane Injection in a Rat Model of Choroidal Neovascularization.
Jong Hyun Lee, Jae Lim Chung, Samin Hong, Hyoung Jun Koh
1Department of Ophthalmology, Ilsan Paik Hospital, Inje University, Goyang-si, Korea.
2Department of Ophthalmology, Yonsei University College of Medicine, The Institute of Vision Research, Seoul, Korea. hjkoh@yuhs.ac
흰쥐를 이용한 실험적 맥락막신생혈관 모델에서 유리체강내 양막 주입의 효과
이종현1ㆍ정재림2ㆍ홍사민2ㆍ고형준2
Department of Ophthalmology, Ilsan Paik Hospital, Inje University1, Goyang-si, Korea, Department of Ophthalmology, Yonsei University College of Medicine, The Institute of Vision Research2, Seoul, Korea
Correspondence:  Jong Hyun Lee, M.D.1
Abstract
PURPOSE
To evaluate the effects of an intravitreal amniotic membrane (AM) injection on a rat model of laser-induced choroidal neovascularization (CNV). METHODS: Intravitreal injection of AM (12.5 microgram/mL) into the left eyes and phosphate-buffered saline into the fellow eyes of 15 rats was performed immediately after laser injury. At week 2, after angiography, the rats were sacrificed, and histopathologic analysis was performed. Angiographic and histopathologic assessments of the effects of AM injection on CNV growth were compared between the two groups. RESULTS: CNV thickness was found to have increased more in the AM treatment group (141.54+/-8.12 micrometer) than in the experimental control group (65.23+/-16.90 micrometer) (p=0.010). CONCLUSIONS: Intravitreal AM injection demonstrated histopathologic pro-angiogenic properties in a rat model of CNV.
Key Words: Amniotic membrane;Angiogenesis;Choroidal neovascularization


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