J Korean Ophthalmol Soc > Volume 49(11); 2008 > Article
Journal of the Korean Ophthalmological Society 2008;49(11):1729-1736.
DOI: https://doi.org/10.3341/jkos.2008.49.11.1729    Published online November 15, 2008.
Efficacy of Vitamin A-containing Lubricant in Dry Eye Syndrome Evaluated by Impression Cytology.
Eun Chul Kim, Choun Ki Joo
Department of Ophthalmology and Visual Science, College of Medicine, The Catholic University of Korea, Seoul, Korea. ckjoo@catholic.ac.k
건성안에서 결막 압흔세포검사를 이용한 비타민 A 함유 누액의 치료효과의 평가
김은철ㆍ주천기
Efficacy of Vitamin A-containing Lubricant in Dry Eye Syndrome Evaluated by Impression Cytology
Abstract
PURPOSE
To evaluate the therapeutic effect of topical vitamin A-containing lubricant in dry eye patients. METHODS: Three hundred eyes of 150 patients with dry eye (Schirmer I test< or =10 mm, BUT< or =10 seconds) were divided into three groups. Preservative-containing artificial tears, preservative-free artificial tears, and vitamin A-containing lubricant were administrated to Groups 1, 2, and 3, respectively (N=50). We evaluated and checked symptom scores, tear film breakup time (tBUT), Schirmer I test results, corneal fluorescein stain scores, and impression cytology immediately and at 1, 2, and 3 months after treatment. RESULTS: Mean tBUT and goblet cell density significantly increased from 5.06+/-1.25 to 6.76+/-1.21 sec and from 125.62+/-61.52 to 192.86+/-69.38 cell/mm2, respectively, after 2 months in group 3 (P<0.05). Impression cytology grade significantly decreased from 2.14+/-0.38 to 1.67+/-0.41 after 2 months in group 3 (P<0.05). The Schirmer I test score significantly increased from 9.12+/-4.15 to 12.83+/-0.96 mm, and the corneal stain score decreased from 2.13+/-0.95 to 1.18+/-0.68 after 3 months in group 3 (P<0.05). CONCLUSIONS: The improvement of symptoms and the stabilization of tear films and ocular surfaces suggested that treatment with vitamin A-containing lubricant for dry eye was effective.
Key Words: Dry eye;Impression cytology;Vitamin A-containing lubricant
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