| The Development of Biodegradable Intrascleral Implant for Slow Releasing of Triamcinolone Acetonide. |
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Jun Hun Lee, Jung Hoon Lim, Young A Han, Jae Pil Shin, Kyung Sin Cho, Jeong Ok Lim, Si Yeol Kim |
1Department of Ophthalmology, Kyungpook National University, College of Medicine, Daegu, Korea. kimsy@knu.ac.kr
2Department of Biomedical Engineering, Kyungpook National University, College of Medicine, Daegu, Korea.
3Department of Ophthalmology, Cheil Eye Hospital, Daegu, Korea. |
| 공막 내 삽입한 생체분해성 고분자 매트릭스를 이용한 스테로이드 지속 방출 방법의 개발 |
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이준훈1,임정훈3,한영아2,신재필1,조경신1,임정옥2,김시열1 |
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Department of Ophthalmology, Kyungpook National University, College of Medicine1, Daegu, Korea Department of Biomedical Engineering, Kyungpook National University, College of Medicine2, Daegu, Korea Department of Ophthalmology, Cheil Eye Hospital3, Daegu, Korea |
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Correspondence:
Jun-Hun Lee, M.D.1 |
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| Abstract |
PURPOSE
In order to treat inflammatory and proliferative disorders of the posterior segment of the eye, the authors evaluated the use of a biodegradable intrascleral implant for slow release of triamcinolone acetonide (TA). METHODS: The intrascleral implant (1 mm thick and 3 mm in diameter) was made of alginic acid and PLA (poly (D, L-lactide)) containing 4 mg of TA. In vitro release of TA was evaluated by HPLC. To evaluate in vivo release of TA, the implant was placed into a scleral pocket in 18 rabbit eyes and the concentrations of TA in the aqueous humor, vitreous, and retina-choroid-sclera were measured by HPLC at 1, 2, 4, 8, and 12 weeks after implantation. The toxicity and biocompatibility of the implant were evaluated by slit lamp examination, IOP, electroretinogram, and light microscopy. RESULTS: In vitro study demonstrated that the implant released TA in controlled manner for at least 8 months. The TA detected in the vitreous after 8 to 12 weeks and was not detected in retina-choroid-sclera at 8 weeks after implantation. The TA was not detected in aqueous humor. No significant toxicity to the retina was observed. CONCLUSIONS: These results suggest that the intrascleral implant of TA could be a promising system for the delivery of steroids to the posterior segment of eye in cases of inflammatory or proliferative disorders of posterior segment. |
| Key Words:
Alginic acid;Intrascleral implant;PLA;Sustained drug delivery;Triamcinolone acetonide |
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