| Ahmed Valve Implantation Result and TGF-beta and VEGF in the Aqueous Humor of Neovascular Glaucoma Patients. |
|
Won Kyung Song, Jun Haeng Lee, Young Jae Hong, Chan Yun Kim |
|
The Institute of Vision Research, Department of Ophthalmology, Yonsei University College of Medicine, Hospital, Seoul, Korea. kcyeye@yahoo.co.kr |
| 신생혈관녹내장 환자의 방수내 변형성장인자-β와 혈관내피성장인자 농도와 아메드밸브 수술 결과 |
|
송원경,이준행,홍영재,김찬윤 |
|
The Institute of Vision Research, Department of Ophthalmology, Yonsei University College of Medicine, Hospital, Seoul, Korea |
|
Correspondence:
Won Kyung Song, M.D. |
|
|
| Abstract |
PURPOSE
To assess the relationship of transforming growth factor-beta (TGF-beta) and vascular endothelial growth factor (VEGF) levels in the aqueous humor of neovascular glaucoma (NVG) patients and the results of Ahmed valve implantation surgery. METHODS: We compared surgical outcomes of NVG patients who underwent Ahmed valve implant surgery from January 2002 through October 2002 at severance hospital with levels of TGF-beta1, TGF-beta2 and VEGF in the aqueous humors of these patients. RESULTS: Nineteen eyes (19 patients) were analyzed in the study. The success of surgery was defined as intraocular pressure maintained as 6-20 mm Hg regardless of additional glaucoma medications taken. Twelve eyes (63%) satisfied successful surgery. TGF-beta1 concentration was 1.51 ng/ml in the success group and 2.31 ng/ml in the failed group (p=0.295). TGF-beta2 concentration was 5.19 ng/ml in the success group and 5.73 ng/ml in the failed group (p=0.367). VEGF concentration was 10.21 ng/ml in the success group and 9.87 ng/ml in the failed group (p=0.516). All showed no statistical difference between the groups. CONCLUSIONS: In our study, no significant relationship between levels of TGF-beta1, TGF-beta2, or VEGF in the aqueous humor and the surgical outcomes of Ahmed valve implantation were found in patients with NVG. |
| Key Words:
Ahmed valve;Neovascular glaucoma;Transforming growth factor-beta;Vascular endothelial growth factor |
|
PDF Links
Download Citation
