Journal of the Korean Ophthalmological Society 2004;45(4):552-556.
Published online April 1, 2004.
Relationship between Dry Eye Syndrome and Hormone Replacement Therapy in Postmenopausal Women.
Sung Chul Kim, Youn Suh, Sung Kun Chung
Department of Ophthalmology, St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
폐경기 여성에서 호르몬 대치요법과 안구 건조 증상과의 관계
김성철 ( Kim Seong Cheol ) , 서연 ( Seo Yeon ) , 정성근 ( Jeong Seong Geun )
An investigation was carried out into the relationship between dry eye syndrome and hormone replacement therapy(HRT) in postmenopausal women METHODS: A retrospective analysis was made of the symptomatic differences between 100 and 25 postmenopausal women suffering from dry eye symptoms who had either undergone, or not, HRT, respectively. RESULTS: The average total time period of HRT in 57 of the patients was 41.4months, (ranging form 2 to 180 months) in 57 patients. 16 patients had received an estrogen only regimen, and 41 a combination therapy, consisting of both estrogen and progesterone. The Schirmer test results and the tear film break-up times(BUT) in these two groups were 7.29 +/- 4.29 and 6.59 +/- 4.64 mm, and 5.00 +/- 2.47 and 4.95 +/- 2.35 seconds, respectively. No significant difference in the results was found between the two groups. The Schirmer test and BUT results in the HRT patients averaged 6.75 +/- 4.50 mm, and 4.95 +/- 2.37 seconds, respectively. The results showed a statistically significant decrease (p<0.05) for the non-HRT patients, with Schirmer test and BUT results of 11.73 +/- 7.09 mm, and 8.65 +/- 4.50 seconds, respectively. CONCLUSIONS: The total time period and the type of HRT regimen had no influence on the severity of the dry eye symptoms in postmenopausal women. However, when compared to non-HRT patients, the degree of symptomatic manifestations showed statistically significant increases. Further observations and follow-up on these subjects should be pursued.
Key Words: Dry eye syndrome;Hormone replacement therapy;Shirmer test;Tear film break-up time

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