Effects of the Antihypertensive Drugs on the Choroidal Blood Flow in Rabbits.

Kang, Nae Youl; Youn, Won Shik

Original Article

Journal of the Korean Ophthalmological Society 1968;9(2):13-18.

Effects of the Antihypertensive Drugs on the Choroidal Blood Flow in Rabbits.

Nae Youl Kang, Won Shik Youn

Department of Ophthalmology, College of Medicine, Seoul National University, Seoul, Korea.

혈압강하제가 (血壓降下劑) 맥락막혈류량에 (脈絡膜血流量) 미치는 영향 (影響)

윤원식(Won Sik Yoon),강내열(Nae Yeol Kang)

Abstract

The effects of antihypertensive drugs on the choroidal blood flow in rabbits were studied by an apparatus based on the principle of internal calorimetry of Grayson. Thermistors, as the sensing elements, were fastened on the scleral surface of the eye, and determinations were performed up to 60 minutes after intravenous administrations of drugs. The drugs studied were: ganglion blocking agents (pentholinium tartarate, 4 mg; hexamethonium bromide, 1 mg; and mecamylamine chloride, 0.15mg), alpha-methyldopa, 4 mg; guanethidine, 0.5 mg; reserpine, 0.2 mg; hydralazine, 5 mg; and diuretics (dichlorothiazide, 2.5 mg; frusemide, 2.5 mg). Except the diuretics, all the drugs employed produced considerable increase in the choroidal blood flow. The relationships between blood pressure, intraocular pressure and the choroidal blood flow were discussed and the clinical applications were suggested.