The Short Term Effects of Bimatoprost on Optic Nerve Head and Peripapillary Retinal Blood Flow. |
Sun Woong Kim, Chan Yun Kim, Gong Je Seong |
The Institute of Vision Research, Department of Ophthalmology, Yonsei University College of Medicine, Seoul, Korea. gjseong@yumc.yonsei.ac.kr |
Bimatoprost가 시신경유두 및 망막혈류에 미치는 단기효과 |
김선웅 ( Sun Woong Kim ) , 김찬윤 ( Chan Yun Kim ) , 성공제 ( Gong Je Seong ) |
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Abstract |
PURPOSE To demonstrate the effects of bimatoprost on the optic nerve head (ONH) and peripapillary retinal blood flow. METHODS: Sixteen healthy volunteers were recruited. In a randomized, double-blind design, one eye received a drop of bimatoprost and the other eye a drop of placebo. ONH and peripapillary retinal blood flow parameters (flow, volume, velocity) were measured with HRF before, and at 1, 6 and 24 hours after eyedrops and blood pressure (BP), heart rate (HR), and intraocular pressure (IOP) were recorded. RESULTS: The 16 subjects comprised 13 males and 3 females with a mean age of 27.3 +/- 2.4 years. IOP decreased significantly in the bimatoprost-treated eyes at 1, 6 and 24 hours after eyedrops (p<0.05). BP and HR were unchanged after bimatoprost eyedrops. The flow was significantly higher in the temporal peripapillary retina in the bimatoprost-treated eyes 1 hour after eyedrops and the velocity was also higher 6 hours after eyedrops at the same location. At the optic disc, there was a significant increase of the volume in the bimatoprost group 1 hour after eyedrops. There was no significant decrease of HRF parameters in the bimatoprost-treated eyes. CONCLUSIONS: These results suggest that bimatoprost does not have any adverse effect on ONH or peripapillary retinal blood flow. |
Key Words:
Bimatoprost;Ocular Blood flow;Optic nerve head;Peripapillary retina |
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