Journal of the Korean Ophthalmological Society 2004;45(8):1322-1329.
Published online August 1, 2004.
The Short Term Effects of Bimatoprost on Optic Nerve Head and Peripapillary Retinal Blood Flow.
Sun Woong Kim, Chan Yun Kim, Gong Je Seong
The Institute of Vision Research, Department of Ophthalmology, Yonsei University College of Medicine, Seoul, Korea. gjseong@yumc.yonsei.ac.kr
Bimatoprost가 시신경유두 및 망막혈류에 미치는 단기효과
김선웅 ( Sun Woong Kim ) , 김찬윤 ( Chan Yun Kim ) , 성공제 ( Gong Je Seong )
Abstract
PURPOSE
To demonstrate the effects of bimatoprost on the optic nerve head (ONH) and peripapillary retinal blood flow. METHODS: Sixteen healthy volunteers were recruited. In a randomized, double-blind design, one eye received a drop of bimatoprost and the other eye a drop of placebo. ONH and peripapillary retinal blood flow parameters (flow, volume, velocity) were measured with HRF before, and at 1, 6 and 24 hours after eyedrops and blood pressure (BP), heart rate (HR), and intraocular pressure (IOP) were recorded. RESULTS: The 16 subjects comprised 13 males and 3 females with a mean age of 27.3 +/- 2.4 years. IOP decreased significantly in the bimatoprost-treated eyes at 1, 6 and 24 hours after eyedrops (p<0.05). BP and HR were unchanged after bimatoprost eyedrops. The flow was significantly higher in the temporal peripapillary retina in the bimatoprost-treated eyes 1 hour after eyedrops and the velocity was also higher 6 hours after eyedrops at the same location. At the optic disc, there was a significant increase of the volume in the bimatoprost group 1 hour after eyedrops. There was no significant decrease of HRF parameters in the bimatoprost-treated eyes. CONCLUSIONS: These results suggest that bimatoprost does not have any adverse effect on ONH or peripapillary retinal blood flow.
Key Words: Bimatoprost;Ocular Blood flow;Optic nerve head;Peripapillary retina


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