Journal of the Korean Ophthalmological Society 2004;45(8):1356-1362.
Published online August 1, 2004.
Changes of Natural Killer T Cells in Behcet's Uveitis.
Jae Kyoun Ahn, Hyeong Gon Yu, Young Joo Kim, Sung Jun Kim, Young Suk Yu, Hum Chung
1Department of ophthalmology, Seoul National University College of Medicine, Seoul, Korea. hgonyu@snu.ac.kr
2Seoul Artificial Eye Center, Seoul National University Hospital Clinical Research Institute, Seoul, Korea.
베체트 포도막염에서 자연살해 T 세포의 변화
안재균 ( Jae Kyoun Ahn ) , 유형곤 ( Hyeong Gon Yu ) , 김영주 ( Young Joo Kim ) , 김성준 ( Sung Jun Kim ) , 유영석 ( Young Suk Yu ) , 정흠 ( Hum Chung )
Abstract
PURPOSE
To determine the phenotypic and functional changes of circulating CD56+ T cells in ocular Behcet's disease (BD) according to the intraocular inflammatory activity METHODS: Forty patients with BD were divided into two groups according to the inflammatory activity (active; 20, inactive; 20). Twenty patients with acute anterior uveitis and 20 healthy subjects were used as controls. Populations of T lymphocytes subsets in the peripheral blood were determined by flow cytometric analysis, using monoclonal antibodies for CD3, CD4, CD8, CD56, pan alpha beta TCR, pan gamma delta TCR, and V alpha24. The frequencies of intracellular cytokine (IFN-gamma and IL-4) were measured in circulating T cells. RESULTS: CD56 expression was significantly upregulated on CD3+ T cells in active BD compared with those of inactive BD which showed similar data as acute anterior uveitis and healthy subjects (p<0.05). This upregulated expression of CD56 was prominent in CD8(high) T and gamma delta T subsets. The frequencies of IFN-gamma production on circulating T cells were increased in active BD while the frequencies of IL-4 producing cells were decreased, and these trends were prominent in the subsets of CD56+ T cells. CONCLUSIONS: Circulating T cells with CD56 expression are phenotypically and functionally upregulated according to the inflammatory activity of BD. This suggests that CD56+ T cells may play a pathogenic role in maintenance of ocular inflammation in BD.
Key Words: Behcet's disease;IFN-gamma;Th1;CD3+CD56+ T;CD8highCD56+ T


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