ReVersible Change of Vision in Patients Receiving Deferoxamine.

Park, Myung Jin; Cho, Moon Sik; Kim, Joon Soon

Case Report

Journal of the Korean Ophthalmological Society 2004;45(8):1397-1401.
Published online August 1, 2004.

ReVersible Change of Vision in Patients Receiving Deferoxamine.

Myung Jin Park, Moon Sik Cho, Joon Soon Kim

Department of Ophthalmology, Soonchunhyang University College of Medicine, Chunan, Korea. cms3445@hanmir.com

Paraquat 중독 치료시 Deferoxamine에 의한 가역적 시력저하를 보인 증례

박명진 ( Myung Jin Park ) , 조문식 ( Moon Sik Cho ) , 김준순 ( Joon Soon Kim )

Abstract

PURPOSE
To report 2 cases of acute visual neurotoxicity in patients with paraquat poisoning receiving deferoxamine. METHODS: A 48-year-old woman and a 37-year-old man received intravenous infusion of deferoxamine at 3g/day for 7 days for treatment of paraquat poisoning. They presented with severely impaired visual acuity, generalized constriction of visual field, and decreased amplitude of visual evoked potential. They improved clinically upon drug-withdrawal. CONCLUSIONS: Deferoxamine is an effective agent for treatment of paraquat poisoning, but can cause visual neurotoxicity. We recommend careful regulation of the deferoxamine dosage and serial visual monitoring in patients receiving the drug.

Key Words: Deferoxamine;Paraquat;Visual neurotoxicity