| Histologic Characteristics in the Eyes of DBA/2J Mice according to the Degree of Intraocular Pressure. |
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Myoung Hee Park, Do Hyun Kim, Yong Woo Im, Jung Il Moon |
1Department of Ophthalmology, College of Medicine, The Catholic University of Korea, Seoul, Korea. jimoon@catholic.ac.kr
2Apgujung St. Mary's Eye Center, Seoul, Korea. |
| DBA/2J 생쥐 안구의 안압에 따른 조직해부학적 특징 |
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박명희 ( Myoung Hee Park ) , 김도현 ( Do Hyun Kim ) , 임용우 ( Yong Woo Im ) , 문정일 ( Jung Il Moon ) |
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| Abstract |
PURPOSE
We assessed the correlation between ocular abnormalities and the degree of intraocular pressure (IOP) in the DBA/2J (D2) transgenic mice which were proven to have pigmentary dispersion syndrome and developing glaucoma. METHODS: Nine-months-old D2 mice were examined with biomicroscopy under anesthesia and measured for IOP by Tono-Pen, Hematoxylin and eosin staining was performed on the eye sections of the mice to analyze differences between the low-grade IOP group and the high-grade IOP group. RESULTS: Ocular abnormalities including iris pigment loss, iris transillumination, iris stromal atrophy, anterior synechia, thinning of the retina, and ganglion cell loss were found; all of which appeared to be pressure- dependent. CONCLUSIONS: These results corroborate that both IOP and age might be considered for studies using D2 mice, and suggest that D2 mice are a useful glaucoma model to study the mechanisms of retinal ganglion cell death and to evaluate strategies for neuroprotection. |
| Key Words:
DBA/2J mice;Glaucoma;Intraocular pressure;Mouse model;Ocular abnormality |
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