Photodynamic Therapy in Practice: A Review of Experiences with Myopic CNV in Korean Patients.

Chung, Eun Jee; Oh, Hyun Sub; Koh, Hyoung Jun; Lee, Sung Chul; Kwon, Oh Woong

Original Article

Journal of the Korean Ophthalmological Society 2005;46(4):664-670.
Published online April 30, 2005.

Photodynamic Therapy in Practice: A Review of Experiences with Myopic CNV in Korean Patients.

Eun Jee Chung, Hyun Sub Oh, Hyoung Jun Koh, Sung Chul Lee, Oh Woong Kwon

The Institute of Vision Research Department of Ophthalmology, College of Medicine, Yonsei University, Seoul, Korea. owkwon0301@yumc.yonsei.ac.kr

병적 근시와 동반된 맥락막 신생혈관에서 광역학 치료의 임상 적용

정은지,오현섭,고형준,이성철,권오웅

The Institute of Vision Research Department of Ophthalmology, College of Medicine, Yonsei University, Seoul, Korea

Correspondence: Eun-Jee Chung, M.D.

Abstract

PURPOSE
To evaluate the effects of photodynamic therapy with verteporfin on visual acuity and fluorescein angiography in choroidal neovascularization (CNV) associated with pathologic myopia and to determine if this treatment could reproduce the results achieved in the Verteporfin in Photodynamic Therapy (VIP) Trial in Korean patients. METHODS: Forty-two eyes of 39 patients with CNV secondary to pathologic myopia were included. A retrospective review of their clinical records and fluorescein angiography was done. The patients underwent photodynamic therapy with verteporfin and were followed up for more than 6 months after the therapy. The change in best corrected visual acuity (BCVA) and leakage in fluorescein angiography were evaluated. RESULTS: The mean age of the patients was 39.6 and mean follow-up period was 23.5 months. The BCVA of the patients improved in 22 (52.4%) eyes, was unchanged in 13 (30.9%), and worsened in 7 (16.7%). The leakage in fluorescein angiography decreased in 25 (59.5%) eyes. CONCLUSIONS: Photodynamic therapy with verteporfin for myopic CNV in Korean patients appeared to be effective in stabilization of the lesions and improvement of visual acuity.

Key Words: Choroidal neovascularization (CNV);Pathologic myopia;Photodynamic therapy (PDT)