The Effect of Intravitreal Melatonin on Rabbit Retina.

Kim, Do Gyun; Sohn, Won Sup; Kwak, Hyung Woo

Original Article

Journal of the Korean Ophthalmological Society 2002;43(9):1781-1788.
Published online September 1, 2002.

The Effect of Intravitreal Melatonin on Rabbit Retina.

Do Gyun Kim, Won Sup Sohn, Hyung Woo Kwak

¹Department of Ophthalmology, College of Medicine, KyungHee University, Korea. hwkwak@khmc.or.kr
²Sohn's Eye Clinic, Korea.

가토에서 유리체강내로 주사된 Melatonin 의 망막에 대한 독성 효과 연구

김도균 ( Do Gyun Kim ) , 손원섭 ( Won Sup Sohn ) , 곽형우 ( Hyung Woo Kwak )

Abstract

PURPOSE
To investigate the effect of intravitreal melatonin on retina in rabbit. METHODS: In four pigmented rabbit, melatonin was intravitreally injected 100 mu g/0.1 ml, 300 mu g/0.1 ml concentration in left eye, DMSO was injected in right eye as control. we examined gross fundus finding and electroretinogram and then light and electronic microscopic findings at 24 hours and 1 week with both eye. RESULTS: intravitreally melatonin injected eye at 100 mu g/0.1 ml, 300 mu g/0.1 ml concentration and control eye at 1 day and 1 week, significant difference was not shown in gross fundus finding, electroretinogram, light and electronic microscopic finding. Additionally edema, toxic effect change was not found in retina. CONCLUSIONS: Intravitreally injected melatonin has not influenced on retina grossly, histologically, physiologically at 100 mu g/0.1 ml and 300 mu g/0.1 ml concentration. Further study is required about toxic effect of melatonin over 300 mu g/0.1 ml concentration and clinical usefulness of melatonin in retina.

Key Words: Antioxidant;Free radical scavenger;Intravitreal injection;Melatonin;Retinal toxicity