Two Cases of Chlorpromazine-induced Corneal and Lenticular Opacity.

Kim, Hyung Soo; Choi, Hyun Jung; Yun, Young Soo

Case Report

Journal of the Korean Ophthalmological Society 2002;43(11):2349-2353.
Published online November 1, 2002.

Two Cases of Chlorpromazine-induced Corneal and Lenticular Opacity.

Hyung Soo Kim, Hyun Jung Choi, Young Soo Yun

Department of Ophthalmology, Pochun CHA University College of Medicine, Pundang CHA Hospital, Sungnam, Korea. hjchoi90@hanmail.net

Chlorpromazine에 의한 각막 및 수정체 혼탁 2예

김형수 ( Hyung Soo Kim ) , 최현정 ( Hyun Jung Choi ) , 윤영수 ( Young Soo Yun )

Abstract

PURPOSE
To report two cases of corneal deposits and anterior capsular opacity after prolonged chlorpromazine therapy METHODS: Two schizophrenic patients using chlorpromazine showed the corneal endothelial opacity and anterior capsular opacity. They complained of deterioration of vision. And one of them was operated for lenticular opacity by extracapsular lens extraction and posterior chamber intraocular lens implantation. CONCLUSIONS: Because chlorpromazine may induce pigmentary deposits in the conjunctiva, cornea, lens, anterior chamber angle and retina, regular ophthalmic examination seems to be necessary in patients under chlorpromazine therapy.

Key Words: Chlorpromazine;Cornea;Lens;Opacity