Journal of the Korean Ophthalmological Society 2002;43(11):2354-2359.
Published online November 1, 2002.
Retinopathy and Keratopathy Associated with Chronic Tamoxifen Medication.
Hwan Joo Suhk, Joon Hong Sohn, Young Hee Yoon
Department of Ophthalmology, College of Medicine, University of Ulsan, Asan Medical Center, Korea. yhyoon@amc.seoul.kr
타목시펜 장기복용과 관련된 망막병증 및 각막병증 1예
석환주 ( Hwan Joo Suhk ) , 손중홍 ( Joon Hong Sohn ) , 윤영희 ( Young Hee Yoon )
Abstract
PURPOSE
Tamoxifen retinopathy is one of the uncommon side effects together with keratopathy, crystalline retinopathy and cystoid macula edema when tamoxifen is administered with high dose to breast cancer patients. We report here a case of retinopathy patient with five years of tamoxifen application. METHOD: A 46 year old female breast cancer patient complained about decreased visual acuity in both eyes after taking total amount of 37.28 g tamoxifen (20 mg/day) for 5 years. Whorl-like superficial corneal opacity was detected and yellowish white macular crystalline deposits were seen in both eyes. Moreover, decreased b wave amplitude of ERG was detected in electroretinography and RPE atrophy was found in FAG. RESULT: The patient stopped taking tamoxifen immediately after diagnosed with tamoxifen retinopathy. Two months later, it showed decreased corneal opacity and improved visual acuity in the left eye but also showed increased macular crystalline deposits in the left eye.
Key Words: Tamoxifen retinopathy;Crystalline deposit;Corneal opacity


ABOUT
BROWSE ARTICLES
EDITORIAL POLICY
FOR CONTRIBUTORS
Editorial Office
SKY 1004 Building #701
50-1 Jungnim-ro, Jung-gu, Seoul 04508, Korea
Tel: +82-2-583-6520    Fax: +82-2-583-6521    E-mail: kos08@ophthalmology.org                

Copyright © 2024 by Korean Ophthalmological Society.

Developed in M2PI

Close layer
prev next