The Neuroprotective Effect of Ginexin on Rat Retinal Ganglion Cell in Optic Nerve Crush Injury Model.

Kang, Ja Heon; Park, Ki Ho; Kim, Yu Jeong; Kim, Joo Hyon; Kwak, Wie Jong

Original Article

Journal of the Korean Ophthalmological Society 2003;44(4):965-970.
Published online April 1, 2003.

The Neuroprotective Effect of Ginexin on Rat Retinal Ganglion Cell in Optic Nerve Crush Injury Model.

Ja Heon Kang, Ki Ho Park, Yu Jeong Kim, Joo Hyon Kim, Wie Jong Kwak

¹Department of Ophthalmology, Seoul Paik Hospital, Inje University1 College of Medicine, Korea.
²Department of Ophthalmology, Seoul National University college of Medicine, Korea. kihopark@snu.ac.kr
³Seoul Artificial Eye Center, Seoul National University Hospital Clinical Research Institute, Korea.
⁴SK Chemical Life Science Research and Development Center, Korea.

시신경 압박손상모델에서 Ginexin(Ginkgo biloba extract)의 쥐 망막신경절세포에 대한 신경보호효과

강자헌 ( Ja Heon Kang ) , 박기호 ( Ki Ho Park ) , 김유정 ( Yu Jeong Kim ) , 김주현 ( Joo Hyon Kim ) , 곽의종 ( Wie Jong Kwak )

Abstract

PURPOSE
To investigate the neuroprotective effect of Ginexin (Ginkgo biloba extract) on rat retinal ganglion cell in the optic nerve crush injury model. METHODS: From 1 week before the optic nerve injury, Ginexin 100 mg/kg/day (100 mg group), 200 mg/kg/day (200 mg group) or carboxymethylcellulose as a control group (CMC group) was administrated orally 4 weeks in Spraque-Dawley rats. At 3 weeks after the optic nerve injury, the RGCs were counted and the concentration of intravitreal glutamate was measured. RESULTS: The RGC density of CMC group (103+/-22 cells/mm2) was significantly lower than that of 100 mg group (182+/-39 cells/mm2) and 200 mg group (201+/-63 cells/mm2). There was no difference between the 100 mg group and 200 mg group. The concentration of invtravitreal glutamate did not significantly differ among normal, CMC group, 100 mg group and 200 mg group. CONCLUSIONS: Ginexin increased the survival of the retinal ganglion cell in rat optic nerve crush injury model, but, did not influence on the concentration of intravitreal glutamate.

Key Words: Ginkgo biloba extract;Glutamate;Neuroprotection;Optic nerve crush injury;Retinal ganglion cell