Retinoblastoma.

Han, Hong Joo; Park, Byung Il

Original Article

Journal of the Korean Ophthalmological Society 1970;11(4):59-65.
Published online April 1, 1970.

Retinoblastoma.

Hong Joo Han, Byung Il Park

Department of Ophthalmology, Chunnam University Medical School, Korea.

망막모세포종에 (網膜母細胞腫) 대하여 (對)

박병일(Byung Il Park),한홍주(Hong Joo Hahn)

Abstract

Retinoblastoma has been established as an inheritable disease. To the development of sporadic cases the mutation can be ascrivable. Once the gene has been established, however, it is transmitted as an autosomal dominant characteristics with incomplete penetrance. The cases reported here was established in siblings which are of the extremely rare entities. Two families are reported here, which is one of the rare occurence. 1st. Family: The retinoblastoma affect 4 siblings(male, 2. female, 2) in 8 siblings(male, 3. female, 5). Of this 4 cases, 3 died of progression of retinoblastoma, while the one left was in apparent good health with early enucleation. 2 nd. family: Retinoblastoma existed in two siblings(male, 1. female, 1). The male dead 1 year after diagnosis of retinoblastoma and the other one refused radical treatment and lost in follow up.