| Ultrastructure of Corneal Epithelial Cells Foll owing Inoculation of Herpes Simplex Virus in Rabbit. |
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Ji Won Kwon, Jung Hoon Han, Myung Kyoo Ko, Jong Woo Kim |
1Department of Ophthalmology, College of Medicine, University of Ulsan, Asan Medical Center, Seoul, Korea.
2Department of Ophthalmology, College of Medicine, Hanyang University Hospital. |
| 단순포진바이러스 접종후 각막상피세포의 미세구조 |
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권지원(Ji Won Kwon),한정훈(Jung Hoon Han),고명규(Myung Kyoo Ko),김종우(Jong Woo Kim) |
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| Abstract |
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This study was performed to investigate the ultrastructural changes of the infected corneal epithelial cell by herpes simplex virus in rabbit eyes. Herpes simplex virus(type 1, Kos strain)was inoculated on the injured cornea in 5 rabbit. The eyeballs, which was enucleated on days 3, 5, 7, 10 and 14, respectively following the inoculation of herpes simplex virus was examined by the transmission electron microscopy. The intercellular space of the infected corneal epithelial cells were widened with the loss of the desmosomal attachment, followed by the detachment of the adjacent epithelial cell. The nuclear change was characterized by the chromatin clumping, intranuclear inclusion body and virus particles within the nucleus. The basal epithelial cells were detached from the corneal stroma with the relatively well preserved desmosomal attachment between the adjacent epithelial cell. These findings suggest that the intercellular space of the infected corneal epithelial cells was widened, followed by the loss of the epithelial cells. Around 2 weeks following the inoculation of herpes simplex virus, the remodelling of both the corneal epithelial cell-cell and epithelial cell-stromal interface was nearly completed. |
| Key Words:
Cornea;Herpes simplex virus;Keratitis;Ultrastructure |
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