| Outer Blood-retinal Barrier Alteration Induced by Intraocular Ad vanced Glycation Endproduct. |
|
Seok Joon Park, Chung Hum Chung |
1Department of Ophthalmology, Seoul Municipal Boramae Hospital.
2Department of Ophthalmology, College of Medicine, Seoul National University. |
| 토끼 눈 안에 주입된 최종당화산물에 의해 일어나는 외측 망막혈액장벽의 변화 |
|
박석준(Seok Joon Park),정흠(Hum Chung) |
|
|
|
|
| Abstract |
|
Advanced glycation end-product(AGE)is known as a factor causing diabetic retinopathy, but little is known about its effect on the function of outer blood-retinal barrier. To test whether AGE can increase the permeability of outer blood-retinal barrier, we injected glycated albumin into white rabbit eyes and observed the change of the fundus and of the outer blood-retinal barrier permeability. The rabbit retina in medullary ray was thickened in AGE-injected eyes. Intravenously injected microperoxidase, tracer molecule, was found in outer sensory retinal layer and outside of the retinal pigment epithelium in AGE-injected eyes. These results suggest that intraocularly injected AGE can increase the outer blood-retinal barrier permeability. |
| Key Words:
Advanced glycation endproduct;Outer blood-retinal barrier;Permeability |
PDF Links
Download Citation
