| Morphologic Changes of Anterior Chamber Angle and Trabecular Meshwork According to Embryonic Age in Human Fetal Eyes. |
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Jou Weon Youn, Myung Kyoo Ko, Je Geun Chi |
1Department of Ophthalmology, College of Medicine, Hanyang University, Seoul, Korea.
2Department of Pathology, College of Medicine, Seoul National University, Seoul, Korea. |
| 태아안구에서 태령에 따른 전방각 및 섬유주 조직의 형태학적 변화에 대한 연구 |
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윤주원(Jou Weon Youn),지제근(Je Geun Chi),고명규(Myung Kyoo Ko) |
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| Abstract |
PURPOSE
To investigate the morphologic changes of anterior chamber angle and trabecular meshwork during development in human fetal eyes, 77 eyes was enrolled in this study. METHODS: The sequential development of iridocorneal angle and trabecular meshwork were examined using light microscopy in 77 eyes with a gestational age ranged from 7 to 40 weeks. RESULTS: It was found that the presence of openings in the anterior chamber angle lining and aqueous humor drainage was effective by 20~22 weeks of fetal life and intercellular gaps become larger and more frequent as development progresses. During the gestational age(28~30 week), the anterior ahamber was located at the middle of the trabecular meshwork. During the gestational age(32~38 week), the intertra-becular space was widen with the apparent presence of the Schlemm's canal. CONCLUSIONS: The arrest or abnormal differetiation during the gestational period may cause the dysfunction of aqueous humor outflow, to develop congenital glaucoma. |
| Key Words:
Congenital glaucoma;Fetus;Iridocorneal angle;Development;Trabecular meshwork |
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