Study on Fibrovascular Ingrowth into the Intraocular Implant, Medpor(R).

Soe, Sung Guan; Kim, Young Il; Shin, Sung Gyun; Oum, Boo Sup

Original Article

Journal of the Korean Ophthalmological Society 2002;43(7):1310-1322.
Published online July 1, 2002.

Study on Fibrovascular Ingrowth into the Intraocular Implant, Medpor(R).

Sung Guan Soe, Young Il Kim, Sung Gyun Shin, Boo Sup Oum

¹Department of Ophthalmology, Busan Paik Hospital, The Inje University Medical College, Korea. seossg@hanmail.net
²Shin & Park eye clinic, Korea.
³Department of Ophthalmology, College of medicine, Busan national University, Korea.

Medpor(R) 내로의 섬유혈관화에 대한 연구

서성관 ( Sung Guan Soe ) , 김영일 ( Young Il Kim ) , 신성균 ( Sung Gyun Shin ) , 엄부섭 ( Boo Sup Oum )

Abstract

PURPOSE
We investigated the effects of bFGF/Sucralfate/Hydron suspension and hyperbaric oxygen on fibrovascular ingrowth into porous implants materials. METHODS: Eight rabbits underwent bilateral abdominal incision through which porous orbital disc-shaped implants were inserted between abdominal muscles. These implants were either uncoated or coated with suspension of bFGF/Sucralfate/Hydron. Hyperbaric oxygen therapy was performed on 4 selected rabbits for 5 days or 10 days. Implants were harvested after 3 days, 1 week, 2 weeks and 4 weeks. RESULTS: Enhanced fibrovascular ingrowth was shown in bFGF/Sucralfate/Hydron or hyperbaric oxygen treated implants. bFGF/Sucralfate/Hydron treated implants demonstrated more fibrovascularization than hyperbaric oxygen treated implants. CONCLUSIONS: Simultaneous therapy of bFGF/Sucralfate/Hydron and hyperbaric oxygen showed more fibrovascularization than separately treated implants.

Key Words: Basic fibroblast growth factor;Fibrovascular ingrowth;Hyperbaric oxygen therapy;polyethylene (Medpor(R)) implants