Journal of the Korean Ophthalmological Society 2002;43(8):1496-1502.
Published online August 1, 2002.
Correlation of sFas Level with Uveitis Severity.
Jung Won Han, Sang Moon Chung, Tae Won Hahn, Woo Jin Sah, Yong Woo Im, Min Ho Kim
1Department of Ophthalmology, Kangnam St. Mary's Hospital, School of Medicine, The Catholic University of Korea.
2Apgujung St. Mary's Eye Center, Korea.
Soluble Fas 농도와 포도막염 중증도와의 관계
한정원 ( Jung Won Han ) , 정상문 ( Sang Moon Chung ) , 한태원 ( Tae Won Hahn ) , 사우진 ( Woo Jin Sah ) , 임용우 ( Yong Woo Im ) , 김민호 ( Min Ho Kim )
Abstract
PURPOSE
The aim of this study is to determine the soluble Fas (sFas) levels in both sera and aqueous humor in patients with uveitis and compare them to the uveitis severity. METHODS: We measured the sFas levels in both sera and aqueous humor (AH) of patients (n=40) with uveitis and non-uveitis controls (n=27). The patients with uveitis comprised 24 Behcet's disease, 6 panuveitis, 5 anterior uveitis, 2 lens induced uveitis, 1 Vogt-Koyanagi-Harada-disease, 1 sarcoidosis, and 1 retinal vasculitis. The severity of uveitis was determined by the Hogan's grading method (0~4 grade) at the time of sampling. RESULTS:The concentration of aqueous sFas in uveitis patients was significantly higher than that in nonuveitis controls, while there was no difference in the serum concentration of sFas between the two groups. In the paired samples of serum and AH, obtained simultaneously, the aqueous sFas levels were higher than serum Fas levels in patients with uveitis, whereas the non-uveitis controls displayed significantly lower sFas levels in AH than in the serum. The sFas levels in AH or serum were not different between Behcet's uveitis and non-Behcet's uveitis. However, in patients with Behcet's uveitis, circulating sFas strongly correlated with aqueous sFas, which was not so in those with non-Behcet's uveitis. Patients (n=29) with more active (grade> or =2) uveitis had significantly higher levels of aqueous sFas than those (n=11) with less active (grade<2) uveitis. After treatment with steroid and/or immunosuppressive agents, aqueous sFas levels were decreased in parallel with a reduction in the number of inflammatory cells in the anterior chamber. CONCLUSIONS: The levels of sFas were elevated in patients with uveitis and correlated well with uveitis severity.
Key Words: Behcet's uveitis;Soluble Fas;Uveitis severity


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