Comparison of the Intraocular Pressure Reducing E ffect of Latanoprost with Timolol. |
Hyo Lee, Chan Yoon Kim, Ho Kyum Kim, Young Jae Hong |
1The Institute of Vision Research, College of Medicine, Yonsei University, Seoul, Korea. 2Department of Ophthalmology, Yonsei University College of Medicine. 3Department of Ophthalmology, College of Medicine, Hanlim University, Sac. |
Latanoprost 와 Timolol 의 안압하강 효과 비교 |
이효(Hyo Lee),김호겸(Ho Kyum Kim),홍영재(Young Jae Hong),김찬윤(Chan Yoon Kim) |
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Abstract |
We compared the intraocular pressure reducing effect and side effects of 0.005%Latanoprost administered once daily with 0.5%Timolol administered twice daily in patients with open-angle glaucoma or ocular hypertension. This was an open randomized study with two parallel groups and a treatment period of 12 weeks. A total of 76 patients were included:38 in the Latanoprost group and 38 in the Timolol group. Intraocular pressure was reduced from 25.92 mms of mercury to 17.12 mms of mercury[33.91%]with Latanoprost and from 22.53 mms of mercury to 18.38 mms of mercury[18.42%]with Timolol. The efficacy of Latanoprost was statistically superior to timolol[p<0.001]. Latanoprost induced a slight conjunctival hyperemia and ocular discomfort but both drugs were generally well tolerated. Iris hyperpigmentation reported as a significant side effect of Latanoprost was not observed during 12 weeks of follow-up. It is concluded that Latanoprost administered once daily in the evening reduced intraocular pressure as well as and probably more than Timolol administered twice daily. |
Key Words:
Glaucoma;Intraocular pressure;Latanoprost;Timolol |
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