Journal of the Korean Ophthalmological Society 2000;41(2):459-468.
Published online February 1, 2000.
Comparison of the Intraocular Pressure Reducing E ffect of Latanoprost with Timolol.
Hyo Lee, Chan Yoon Kim, Ho Kyum Kim, Young Jae Hong
1The Institute of Vision Research, College of Medicine, Yonsei University, Seoul, Korea.
2Department of Ophthalmology, Yonsei University College of Medicine.
3Department of Ophthalmology, College of Medicine, Hanlim University, Sac.
Latanoprost 와 Timolol 의 안압하강 효과 비교
이효(Hyo Lee),김호겸(Ho Kyum Kim),홍영재(Young Jae Hong),김찬윤(Chan Yoon Kim)
Abstract
We compared the intraocular pressure reducing effect and side effects of 0.005%Latanoprost administered once daily with 0.5%Timolol administered twice daily in patients with open-angle glaucoma or ocular hypertension. This was an open randomized study with two parallel groups and a treatment period of 12 weeks. A total of 76 patients were included:38 in the Latanoprost group and 38 in the Timolol group. Intraocular pressure was reduced from 25.92 mms of mercury to 17.12 mms of mercury[33.91%]with Latanoprost and from 22.53 mms of mercury to 18.38 mms of mercury[18.42%]with Timolol. The efficacy of Latanoprost was statistically superior to timolol[p<0.001]. Latanoprost induced a slight conjunctival hyperemia and ocular discomfort but both drugs were generally well tolerated. Iris hyperpigmentation reported as a significant side effect of Latanoprost was not observed during 12 weeks of follow-up. It is concluded that Latanoprost administered once daily in the evening reduced intraocular pressure as well as and probably more than Timolol administered twice daily.
Key Words: Glaucoma;Intraocular pressure;Latanoprost;Timolol


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