| Effects of Topically Applied Na-Hya luronan on Stromal and Endothelial Healing in Experimental Corneal Alkali Wounds. |
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Yoo Kyung Park, Jang Hyun Chung |
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Department of Ophthalmology, Ewha Womens University, Mokdong Hospital. |
| 가토 각막 알칼리 화상에서 Na-Hyaluronan 국소 점안이 각막 실질과 내피 치유에 미치는 영향 |
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박유경(Yoo Kyung Park),정장현(Jang Hyun Chung) |
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| Abstract |
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The effects of topical sodium-hyaluronan on the stromal and endothelial healing were examined in the repair process of experimental corneal alkali wounds. Corneal alkali wounds were produced in one eye of each rabbit by applying a 5.5 mm round filter paper soaked in 1N NaOH onto the central cornea for 60 seconds. Then the eyes were treated topically with either 1% Na-HA(the treatment group)or a phosphate buffered saline(PBS)(the con-trol group)4 times per day for 3 weeks. Endothelial wound morphometry was performed after alizarin red and trypan blue staining. The stromal healing was assessed by counting polymorphonuclear leukocytes(PMNs)and keratocytes in the central and marginal wounds areas. The stroma treated with Na-HA had less PMNs than that of the control group during the early healing period. The defect area of the endothelium was significantly smaller in the Na-HA treated group than in the control corneas. The present findings indicate that topically applied 1%Na-HA affects stromal and endothelial healing during the early repair process after corneal alkali wounds. |
| Key Words:
Alkali wound;Cornea;Endothelium;Na-Hyaluronan;Stroma |
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