Retinotoxic Effect of Sodium Iodate in the Rabbit.

Kim, Dong Hee; Kwak, Hyung Woo; Kim, Jae Myung

Original Article

Journal of the Korean Ophthalmological Society 1997;38(6):1006-1012.
Published online June 1, 1997.

Retinotoxic Effect of Sodium Iodate in the Rabbit.

Dong Hee Kim, Hyung Woo Kwak, Jae Myung Kim

Department of Ophthalmology, College of Medicine, Kyunghee University, Seoul, Korea.

유색가토에서 요오드산 나트륨에 의한 망막독성

김동희(Dong Hee Kim),곽형우(Hyung Woo Kwak),김재명(Jae Myung Kim)

Abstract

The purpose of this study is to investigate the minimal toxic dose of sodium iodate after the intravenous injection in the pigmented rabbits. Thirteen rabbits were given a intravenous injection of 2% sodium iodate(pH 7.4). The animals were devided into two groups, the 10mg/kg and 25mg/kginjected groups. In ERG findings, the b wave amplitude decreased one week after injection in both groups and was recovered at 5 weeks in the 10mg/kg-injected group, but it was not recovered upto 5 weeks in the 25mg/kg-injected group. In the electron microscopic findings, the abnormal change was not observed in the 10mg/kg-injected group but the pigment epithelium and outer segments of the photoreceptors were markedly destroyed and did not recovered upon the 5 weeks in the 25mg/kg-injected group. Therefore, ultrastructural and functional changes occurred in a 25mg/kg of sodium iodate injected group and those changes were not recovered for the period of 5 weeks after injection.

Key Words: Sodium iodate;Retinal pigment epithelium;ERG;Electron microscopy