Journal of the Korean Ophthalmological Society 1998;39(1):73-79.
Published online January 1, 1998.
The Effect of Hydrophilic Treatment of PMMA Material Using Hydrolysis on Cell Attachment in Vivo (II).
Ji Young Park, Choun Ki Joo, Su Won Seo, Jin Hak Lee
1Department of Ophthalmology, Catholic University Medical College Catholic Research.
2Institutes of Medical Science, Seoul, Korea.
생체 내에서 인공수정체 재질의 친수성 처리가 세포유착에 미치는 영향 ( II )
박지영(Ji Young Park),주천기(Choun Ku Joo),서수원(Su Won Seo),이진학(Jin Hak Lee)
Abstract
PMMA(polymethyl Methacrylate) introcular lens(IOL) has been designed for making surface hydrophobic. Hydrophilic IOL has advantages such as less damage of corneal endothelium and less attachment of inflammatory cells on the IOL surface especially in case of uveitis or diabetes mellitus. Therefore, hydrophilic IOL is regarded as a biocompatible IOL. In this study, we made PMMAs hydrophilic using hydrolysis (described in The Effect of Hydrophilic Treatment of PMMA using Hydrolysis on Light Transmission and Cell Attachment in Vitro (I)). The number of PMMA treated in each condition was twelve and each PMMA has been implanted into rat peritoneal space. These PMMAs were examined with inverted light microscope and scanning electron microscope 3 days and 7-14 days after implantation. The number of cell attachment on pMMA-1 or PMMA-2 was about 1/5 of that on PMMA-0 and the difference was statistically significant (p<0.05). There was no statistically significant difference of cell attachment between PMMA-1 and PMMA-2. The cells on PMMA-0 showed prominent cytoplasmic processes, while those on PMMA-1 or PMMA-2 showed little processes. The majority of the surface PMMA-0 was covered with membrane light sheet. Therefore, it was found that treatment of PMMA with Isopropranol and NaOH was useful in making PMMA dydrophilic and decreasing the cell attachment on PMMA in vivo.
Key Words: After-Cataract;Cataract;Cell attachment;Hydrophilic PMMA;PMMA


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