Journal of the Korean Ophthalmological Society 1996;37(4):602-607.
Published online April 1, 1996.
Effects of Antimetabolites on Proliferation of Rabbit Retinal Pigment Epithelial Cells.
Ho Kyum Kim, Hyung Woo Kwak, Jae Myung Kim
Department of Opthalmology, College of Medicine, Kyung Hee University, Seoul, Korea.
망막색소상피세포 증식에 관한 각 항암제의 효과 분석
김호겸(Ho Kyum Kim),곽형우(Hyung Woo Kwak),김재명(Jae Myung Kim)
Abstract
Inspite of technical advances, the need for pharmacologic treatment of proliferative vitreoretinopathy was increased. In order to evaluate the antiproliferative effect of various antimetabolites to the rabbit retinal pigment epithelial cell, we treated cultured rabbit retinal pigment epithelial cell with different concentration of drugs to perform dose inhibition studies. We found that the antimetabolites inhibited the proliferation of rabbit retinal pigment epithelial cell in a dose dependent and a time dependent manner. The drug concentration required for 50% inhibition of cell growth (ID50) were found to be as follows (BCNU; 6.51 mg/L, 5-FU ; 8.94 mg/L, Daunorubicin; 0.03mg/L, Mitomycin-C; 0.26mg/L).
Key Words: Antimetabolites;ID50;Proliferative Vitreoretinopathy


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