Journal of the Korean Ophthalmological Society 1996;37(11):1907-1914.
Published online November 1, 1996.
Clinical and Histological Study of Extraocular Muscle in Congenital Fibrosis Syndrome.
Young Bae Roh, Jong Hwan Kim, Boo Sup Oum, Sun Yong Baek
Department of Ophthalmology, College of Medicine, Pusan National University, Pusan, Korea.
선천섬유화증후군에서 임상 및 외안근의 조직학적 연구
노영배(Young Bae Roh),김종환(Jong Hwan Kim),엄부섭(Boo Sup Oum),백선용(Sun Yong Baek)
Abstract
The authors analyzed 8 cases of the patients with congenital fibrous syndrome for clinical and histological study. In addition we observed the histological findings for the relationship between the clinical manifestations and fibrosis of the muscles and the cause of the fibrosis. All of the patients had hypotropia and 7 of whom had bilateral tendency, six patients showed exotropia and two patines showed esotropia. Associated ocular problems were amblyopia (88%), ptosis (88%), nisometropia (50%) and nystagmus (62%). The most common abnormal head posture was chin up position (88%). There were improvement of abnormal head position in six patients but no change of abnormal head posture in two patients after operation. In histological study the muscle fiber showed generalized degeneration. Clumping of the nuclei of the muscle fiber was replaced by many nuclei of the fibroblasts in light microscopy. The authors observed the proliferation of the collagen fibers among the fibroblastic nuclei and amorphous diffuse particle stained by lightred color in the intercellular space. In electron microscopy the premature collagen fibers appeared among amorphous particles and some particles had close relationship with collagen fibers. From these findings, it would appear that formation of the collagen fiber occurs in extraocular space and degenerated myofibrils are responsible for the formation of the collagen fiber, and abnormal head posture results from fibrosis of muscle fiber and ptosis.
Key Words: Abnormal head posture;Fibrosis;Histology;Muscle fiber


ABOUT
BROWSE ARTICLES
EDITORIAL POLICY
FOR CONTRIBUTORS
Editorial Office
SKY 1004 Building #701
50-1 Jungnim-ro, Jung-gu, Seoul 04508, Korea
Tel: +82-2-583-6520    Fax: +82-2-583-6521    E-mail: kos08@ophthalmology.org                

Copyright © 2024 by Korean Ophthalmological Society.

Developed in M2PI

Close layer
prev next