Journal of the Korean Ophthalmological Society 1997;38(3):406-412.
Published online March 1, 1997.
Regulation of the Levels of Trabecular Matrix Metalloproteinase and Inhibitor by Transforming Growth Factor-beta1.
Gong Je Seong
1Department of Ophthalmology, Yonsei University College of Medicine.
2Institute of Vision Research, Yonsei University College of Medicine.
Transforming Growth Factor-β1이 Trabecular Matrix Metalloproteinase 와 Inhibitor 의 분비 조절에 미치는 영향
성공제(Gong Je Seong)
The present study investigates the role of TGF-beta1 as one of possible etiologic factors of glaucoma by studying the effect of TGF-beta1 on the secretion of matrix metalloproteinase and tissue inhibitor of matrix metalloproteinase. The cultured samples of trabecular meshwork cells were treated with TGF-beta1 in concentrations of 0, 100, 1000 and 10000 pg/ml. The samples were analysed for the secretion of MMP2 and timp2 through electrophoresis, western blot and TGF-beta1 increased, the secretions of MMP2 and TIMP2 were not significantly changed after 24 hours. But the secretion of MMP2 was decreased while the secretion of TIMP2 was increased after 72 hours. The results suggest that TGFbeta1 may be one of the etilogic factors of glaucoma.
Key Words: glaucoma;TGF-beta1;matrix metalloproteinase;tissue inhibitor

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