The Effects of Minoxidil Versus Mitomycin C on the Filteing Surgery for Glaucoma in Rabbits.

Kim, Yong Yeon; Han, Heon Seung; Lee, Tae Soo

Original Article

Journal of the Korean Ophthalmological Society 1997;38(4):666-673.
Published online April 1, 1997.

The Effects of Minoxidil Versus Mitomycin C on the Filteing Surgery for Glaucoma in Rabbits.

Yong Yeon Kim, Heon Seung Han, Tae Soo Lee

Department of Ophthalmology, Korea University College of Medicine, Seoul, Korea.

녹내장 여과술의 송공에 미치는 Minoxidil 국소점안과 Mitomycin C 국소도포 효과에 대한 비교

김용연(Yong Yeon Kim),한헌승(Heon Seung Han),이태수(Tae Soo Lee)

Abstract

We compared the effect of topical minoxidil after filtering surgery with that of mitomycin C (MMC) application in rabbits. Fourty-nine eyes were divided into the minoxidil-treated eyes, MMC_treated eyes and control eyes. Intraocular pressure (IOP) in minoxidil-treated eyes and MMC-soaked eyes were significantly lower than that of the control eyes at postoperative 1 and 3 days. MMC-soaked eyes had lower IOPs than the minoxidil-treated and control eyes, but IOPs in the minoxidil- and control eyes were similar at days 5 to 21. IOP survival in the MMC-treated eyes was significantly longer than in both the minoxidil-treated and control eyes. These results suggest that topical minoxidil can cause reduction of IOP at the early postoperative period. Howver, the IOP lowering effect of Minoxidil did not last as long as that of MMC soaking. Further study is necessary to enhance the efect of topical minoxidil including its method of application and optimal concentration.

Key Words: Glaucoma filtering surgery;Intraocular pressure;Mitomycin C;Topical minoxidil