Journal of the Korean Ophthalmological Society 1995;36(7):1084-1092.
Published online July 1, 1995.
Delayed Tear Clearance Induced by Botulinum Toxin Injection in Essential Blepharospasm and Hemifacial Spasm.
Jae Chan Kim, Joong Sup Chun, Nae Sun Hong, Bon Sool Koo
1Department of Ophthalmology, School of Medicine, Chung-Ang University, Seoul, Korea.
2Department of Ophthalmology, Sung-Ae General Hospital, Seoul, Korea.
본태성 안검경련 및 반측안면경련증환자에서 Botulinum toxin 주사에 의해 유발되는 delayed tear clearance 에 관한 연구
홍래선(Nae Sun Hong),김재찬(Jae Chan Kim),천중섭(Joong Sup Chun),구본술(Bon Sool Koo)
Abstract
Assuming that botulinum toxin injection can release the involuntary contraction as well as reduce the tear drainage function, mediated by paralysis of orbicularis oculi muscles, then give rise to effect on tear clearance, Authors have examined 18 blepharospasm and 32 hemifacial spasm patients to evaluate the pre- and post- botulinum toxin injectional values of BUT, Schirmer test, and fluolescein clearance test 1, 2, which evaluate possibilities of delayed tear clearanee induced by botulinum toxin injection. Following treatment with botulinum toxin, results of BUT were increased significantly (p<0.0001), values of Schirmer test tended to increase without statistical significance. In fluorescein clearance test 1, length and concentration values were increased significantly(p<0.05), but in fluorescein clearance test 2, only length measurements were increased significantly(p<0.05). And also in blepharospasm cases of BUT values less than 4 second, both Schirmer test and fluorescein clearance test results were increased with statistical significance(p<0.05). We concluded that delayed tear clearance induced by botulinum toxin injection could be effective treatment for facial dystonias, especially combined cases with dry eye.
Key Words: Botulitum toxin injection;Delayed tear clearance;Dry eye


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