| Effect of Long Term use of Topical Antiglaucoma Medications on Aqueous Humor in Rabbits. |
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Sang Woo Lee, Sung Min Hyung, Byung Heon Ahn, Seung Ryul Kim |
1Department of Ophthalmology, College of Medicine, Chungbuk National Unversity, Chungbuk, Korea.
2Department of Ophthalmology, College of Medicine, Chungnam National Unversity, Chungnam, Korea.
3Department of Biochemistry, College of Medicine, Chungbuk National Unversity, Chungbuk, Korea. |
| 장기간 투여한 안압하강제가 가토방수에 미치는 영향 |
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이상우(Sang Woo Lee),형성민(Sung Min Hyung),안병헌(Byung Heon Ahn),김승렬(Seung Ryul Kim) |
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| Abstract |
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Various studies have been performed to identify change in the constituents of aqueous humor which was suggested either as a factor for fibroblast proliferation causing glaucoma filtering bleb failure or as a factor for the pathogenesis of primary open angle glaucoma. This study was designed to investigate change of aqueous humor composition after long-term topical antiglaucoma medication. After 16-week instillation of pilocarpine 4% and Betagan(TM) in ten rabbits, aqueous humor was obtained from eight control and eight experimental eyes. Protein bands were identified by SDS-PAGE and gold staining techniques. The density and distribution of these protein bands was significantly different between the two groups. The result of this study may give help for future study of pathogenesis of primary open angle glaucoma and causes of high failure rate after glaucoma filtration surgery in patients on chronic topical antiglaucoma medication. |
| Key Words:
Anti-glaucoma medication;Aqueous humor composition;Protein band |
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