Experimental Corneoacleral Limbal Wound Repair with Cyanoacrylate Glue and 8-0 Vicryl on Rabbits.

Lee, Jae Sun; Cho, Sung Gi; Choi, Sang Kyoung

Original Article

Journal of the Korean Ophthalmological Society 1989;30(6):899-905.
Published online June 1, 1989.

Experimental Corneoacleral Limbal Wound Repair with Cyanoacrylate Glue and 8-0 Vicryl on Rabbits.

Jae Sun Lee, Sung Gi Cho, Sang Kyoung Choi

Department of Ophthalmology, Korea Veterans Hospital, Korea.

가토에서 Cyanoacrylate Glue 와 8 - 0 Vicryl 을 사용한 실험적 각공막윤부 절개창 접합

이재선(Jae Sun Lee),조성기(Sung Gi Cho),최상경(Sang Kyoung Choi)

Abstract

To evaluate the availability of n-butyl-2-cyanoacrylate as an adhesive in limbal wound repair, we used 15 rabbits(30 eyes). A limbal incision exactly 9mm long was made and the wound of one eye was tightly closed with seven equally apaced corneoscleral sutures of 10-0 nylon(nylon group), The wound of the other eye was closed by two(6.5mm spaced, 11 and 1 o'clock) corneoscleral sutures of 8-0 vicryl and the outer surface of this limbal wound was thinly coated with a small amount of Histoacryl(Histo-acryl group). The average disrupting pressure in nylon group was 0.87 +/- 0.11 kg/cm2 and that in Histoacryl group was 0.79 +/- 0.17 kg/cm2. The average refractive change in nylon group was 2.5 diopter with-the-rule astigmatism, and that in Histoacryl group was 0.9 diopter against-the-rule astigmatism. A moderate inflammatory reaction was noted at the histopathologic findings of the wounds closed with Histoacryl 14 days after operation. From the results, post-operative inflammatory changes indicated that the Histoacryl seemed to be rather unsuitable for clinical application.

Key Words: Histoacryl;inflammatory reaction;limbal wound repair