The Effects of Aprotinin of Experimental Corneal Burn in Rabbits.

Kim, Jae Chan; Moon, Yeon Sung; Lee, Ho Keol; Shyn, Kyung Hwan

Original Article

Journal of the Korean Ophthalmological Society 1992;33(11):1043-1048.
Published online November 1, 1992.

The Effects of Aprotinin of Experimental Corneal Burn in Rabbits.

Jae Chan Kim, Yeon Sung Moon, Ho Keol Lee, Kyung Hwan Shyn

Department of Ophthalmology, Chung-Ang University College of Medicine, Seoul, Korea.

가토에서 인위적 각막 화상시 Aprotinin 의 효과

김재찬(Jae Chan Kim),문연성(Yeon Sung Moon),이호걸(Ho Keol Lee),신경환(Kyung Hwan Shyn)

Abstract

Recently, many works to treat chronic corneal ulcer have been progressed. It has been reported that the Aprotinin, one of them, is serine protease inhibitor and is useful to treat therapy-resistant chronic corneal ulcer because it decreases the plasmin level in tear fluid that was increased in corneal ulcer. We performed this study to evaluate the effect of Aprotinin to the reepithelization of cornea according to its concentration. We made corneal burn in rabbits and instilled topical antibiotics and Aprotinin 500u/ml and 200u/ml, four times a day. After instillation, we compared the process of corneal epithelial wound healing, according to the time interval, clinically and histopathologically in each group. As a result, wound healing of cornea treated with combination of antibiotics and Aprotinin was delayed rather than that treated with antibiotics only. And combination therapy with Aprotinin 500n/ml is more effective than with Aprotinin 2000n/ml. This data suggests that high concentration of Aprotinin alone is not helpful to tresat the therapyresistant chronic corneal ulcer.

Key Words: Antibiotics;Aprotinin;Chronic corneal ulcer;Reepithelization