Journal of the Korean Ophthalmological Society 1989;30(3):357-361.
Published online March 1, 1989.
Clinical Effect of Acyclovir Therapy on Herpetic Keratitis.
Young Ki Song, Han Ki Chang
Department of Ophthalmology, Wallace Memorial Baptist Hospital, Pusan, Korea.
헤르페스 각막염 치료에 대한 Acyclovir 의 임상적 효과
송영기(Young Ki Song),장한기(Han Ki Chang)
Abstract
Acyclovir is highly selective and relatively non-toxic anti-herpes agent. Thirt-y-seven patients with herpetic keratitis were treated with acyclovir. (23 patients with pure epithelial type, 4 patients with accompanying stromal keratitis, and 10 patients with accompanying keratouveitis). Acyclovir was very effective in 23 patients with pure epithelial herpetic keratitis. All epithelial defects healed in a mean healing time of 6.2 +/- 2.3 days. In 4 patients with stromal keratitis, 3 patients healed within 14 days and 1 patient healed on 27 days. In 10 patients with keratouveitis, 8 patients healed within 14 days, 1 patient healed on 21 days, and 1 patient was not healed even after one month. Four patients developed superficial punctate keratopathy during therapy, but no other serious adverse effects were seen.


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