J Korean Ophthalmol Soc > Volume 58(8); 2017 > Article
Journal of the Korean Ophthalmological Society 2017;58(8):998-1002.
DOI: https://doi.org/10.3341/jkos.2017.58.8.998    Published online August 15, 2017.
A Case of Recurrent Myxomatous Corneal Degeneration Treated by Interferon Alpha-2b.
Young Myoung Park, Min Ahn, Wan Seok Kang, In Cheon You
1Department of Ophthalmology, Chonbuk National University Medical School, Jeonju, Korea. you2ic@daum.net
2Research Institute of Clinical Medicine, Chonbuk National University, Jeonju, Korea.
3Biomedical Research Institute, Chonbuk National University Hospital, Jeonju, Korea.
점안 인터페론 Alpha-2b로 재발을 억제한 재발 점액종성 각막변성 1예
박영명1⋅안 민1,2,3⋅강완석1⋅유인천1,2,3
전북대학교 의학전문대학원 안과학교실1, 전북대학교 임상의학연구소2, 전북대학교병원 의생명연구원3
Correspondence:  In Cheon You,
Email: you2ic@daum.net
Received: 18 May 2017   • Revised: 4 July 2017   • Accepted: 21 July 2017
Abstract
PURPOSE
To report a case of recurrent myxomatous corneal degeneration after pterygectomy. CASE SUMMARY: A 65-year-old man with a history of abdominal keloid was referred to our hospital for assessment of a well-circumscribed, gelatinous, whitish corneal mass on the nasal corneal area of the left eye that appeared one month prior. The patient had undergone pterygectomy on his left eye 2 years ago. The patient experienced mild foreign body sensation. The other anterior segment and fundus examination of the left eye were both normal. We diagnosed the case as keloid and we performed excisional biopsy of the corneal mass. Histologic findings revealed proliferation of myxoid-appearing material in the anterior corneal stroma. On immunohistochemical examination, sections were stained positive for actin and calretinin, and negative for S-100. We diagnosed the tumor as myxomatous corneal degeneration. After six months, a recurrent mass was found on the previously excised site. Re-excisional biopsy and topical interferon α-2b treatment were then performed in response. After re-excision, there was no recurrence or complications during one year follow-up. CONCLUSIONS: Myxomatous corneal degeneration should be considered during differential diagnosis of an elevated, whitish, gelatinous lesion of the cornea with previous history of trauma or operation, such as pterygectomy. An interferon α-2b topical treatment is useful for recurrent corneal myomatous degeneration.
Key Words: Corneal mass;Interferon α-2b;Myxomatous corneal degeneration;Pterygectomy


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