J Korean Ophthalmol Soc > Volume 58(11); 2017 > Article
Journal of the Korean Ophthalmological Society 2017;58(11):1307-1312.
DOI: https://doi.org/10.3341/jkos.2017.58.11.1307    Published online November 15, 2017.
Hyper-proliferation of Glial Tissues Following Autologous Internal Limiting Membrane Transplantation in Idiopathic Large Macular Holes.
Jong Ho Park, Jae Woo Jung, Seung Min Lee, Sung Who Park, Ji Eun Lee, Ik Soo Byon
1Department of Ophthalmology, Pusan National University Yangsan Hospital, Yangsan, Korea. isbyon@pusan.ac.kr
2Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, Korea.
3Department of Ophthalmology, Pusan National University Hospital, Busan, Korea.
4Medical Research Institute, Pusan National University Hospital, Busan, Korea.
5Department of Ophthalmology, Pusan National University School of Medicine, Yangsan, Korea.
큰 황반원공 환자에서 내경계막 자가이식술 후 발생한 교세포 과증식
박종호1,2⋅정재우1⋅이승민1,2⋅박성후3,4,5⋅이지은3,4,5⋅변익수1,2,5
양산부산대학교병원 안과1, 양산부산대학교병원 의생명융합연구소2, 부산대학교병원 안과3, 부산대학교병원 의생명연구소4, 부산대학교 의과대학 안과학교실5
Correspondence:  Ik Soo Byon,
Email: isbyon@pusan.ac.kr
Received: 20 July 2017   • Revised: 20 September 2017   • Accepted: 26 October 2017
Abstract
PURPOSE
To report three cases of glial hyper-proliferation after autologous internal limiting membrane (ILM) transplantation in idiopathic large macular holes. CASE SUMMARY: Three eyes with full thickness macular holes >500 µm underwent autologous ILM transplantation. After surgery, the macular hole was closed and foveal contour was U-shaped. Optical coherence tomography revealed long-lasting proliferation of glial cells in the fovea after the hole closure. This glial proliferation continued for 6 months, with improved visual acuity, and bump-like features of the fovea. CONCLUSIONS: Autologous transplantation of ILM effectively induced long-lasting proliferation of glial cells, thereby achieving the closure of large macular holes. However, an abnormality of the foveal contour may develop after the hole closure in some cases.
Key Words: Autologous internal limiting membrane transplantation;Glial cell;Hyper-proliferation;Macular hole


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