J Korean Ophthalmol Soc > Volume 58(12); 2017 > Article
Journal of the Korean Ophthalmological Society 2017;58(12):1367-1375.
DOI: https://doi.org/10.3341/jkos.2017.58.12.1367    Published online December 15, 2017.
Factors Related to Refractory Macular Edema in Branch Retinal Vein Occlusion.
Ji Hyun Park, Jung Min Park
Department of Ophthalmology, Maryknoll Medical Center, Busan, Korea. pjm1438@hanmail.net
망막분지정맥폐쇄에 동반된 황반부종에서 유리체강 내 베바시주맙 3회 주입 후 비순응 관련 요인
박지현ㆍ박정민
메리놀병원 안과
Correspondence:  Jung Min Park,
Email: pjm1438@hanmail.net
Received: 8 June 2017   • Revised: 13 November 2017   • Accepted: 30 November 2017
Abstract
PURPOSE
To evaluate the factors associated with refractory macular edema (ME) secondary to branch retinal vein occlusion (BRVO) after three times of intravitreal bevacizumab (IVB) injections. METHODS: Ninety eyes of Ninety patients, who were retrospectively reviewed, were treated with IVB of 1.25 mg (0.05 mL) for ME secondary to BRVO, repeated three times at 4-week intervals and then followed-up for at least 4 months after the IVB. The patients were classified as refractory if there was an increase in the mean retinal thickness >150 µm when measured 1 month after the three injections. The patients were divided into two groups: a responsive group (46 eyes) and a refractory group (44 eyes). RESULTS: In univariate logistic regression analyses, age, diabetes mellitus, hypertension, visual acuity, maximal combined response b wave amplitude (Max B amp), maximal combined response B/A ratio (Max B/A), cone response b wave amplitude, subfoveal choroidal thickness (SFCT), and the number of hyperreflective foci (HF) were risk factors for refractory ME of BRVO (p = 0.045, p = 0.010, p = 0.037, p = 0.034, p = 0.003, p = 0.004, p = 0.001, p = 0.001 and p = 0.001, respectively). In backward multivariate logistic regression analyses, age, Max B amp, Max B/A, SFCT and number of HF were risk factors for refractory ME of BRVO (p = 0.024, p = 0.004, p = 0.047, p = 0.033 and p = 0.049, respectively). CONCLUSIONS: Baseline age, Max B amp, Max B/A, SFCT and number of HF predicted the probability of refractory ME secondary to BRVO after IVB.
Key Words: Bevacizumab;Branch retinal vein occlusion;Electroretinogram;Hyperreflective foci;Subfoveal choroidal thickness


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