J Korean Ophthalmol Soc > Volume 59(3); 2018 > Article
Journal of the Korean Ophthalmological Society 2018;59(3):261-267.
DOI: https://doi.org/10.3341/jkos.2018.59.3.261    Published online March 15, 2018.
A Comparison of Retinal Nerve Fiber Layer Thickness Measured Using Five Different Optical Coherence Tomography Devices.
Youn Gon Lee, Young Hoon Hwang
Myung-Gok Eye Research Institute, Department of Ophthalmology, Kim's Eye Hospital, Konyang University College of Medicine, Seoul, Korea. brainh@hanmail.net
다섯 종류의 빛간섭단층촬영기로 측정한 망막신경섬유층 두께 비교
이윤곤⋅황영훈
건양대학교 의과대학 김안과병원 안과학교실 명곡안연구소
Correspondence:  Young Hoon Hwang,
Email: brainh@hanmail.net
Received: 19 October 2017   • Revised: 30 November 2017   • Accepted: 13 February 2018
Abstract
PURPOSE
To compare circumpapillary retinal nerve fiber layer (RNFL) thicknesses as measured using five different optical coherence tomography (OCT) devices. METHODS: RNFL thickness was measured in 32 healthy eyes of 32 subjects using a Cirrus HD-OCT (Carl Zeiss Meditec, Dublin, CA, USA), Spectralis OCT (Heidelberg Engineering, Heidelberg, Germany), Topcon DRI OCT (Topcon, Tokyo, Japan), RS-3000 Advance OCT (NIDEK, Aichi, Japan), and RTVue-100 (Optovue, Fremont, CA, USA). Global and quadrant (superior, nasal, inferior, and temporal) RNFL thicknesses were compared using repeated measures analysis of variance, and the agreement among devices was determined using Bland-Altman analyses. RESULTS: The global RNFL thickness was greatest when measured using the Topcon DRI OCT, with a mean value of 107.5 µm. The mean global RNFL thicknesses measured using the RTVue-100, RS-3000 Advance OCT, and Spectralis OCT were 104.9 ± 8.4, 104.4 ± 9.4, 102.5 ± 8.9 µm, respectively. The Cirrus HD-OCT presented the thinnest RNFL measurement, with a mean value of 97.7 ± 8.7 µm (p < 0.01). A similar pattern was found for the quadrant RNFL thicknesses (p < 0.01). Differences in the global RNFL thicknesses among the devices ranged from 0.5 to 9.9 µm. The limits of agreement of the global RNFL thicknesses evaluated by Bland-Altman analyses ranged from 6.8 to 19.6 µm. CONCLUSIONS: RNFL thicknesses measured using five different OCT devices were not interchangeable and there was a wide limit of agreement. When interpreting RNFL thickness values determined by different devices, caution is advised.
Key Words: Glaucoma;Optical coherence tomography;Retinal nerve fiber layer


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