| Microaneurysm Turnover after the Use of Dexamethasone and Bevacizumab to Treat Diabetic Macular Edema. |
|
Seon Tae Kim, Woo Jin Jeong |
|
Department of Ophthalmology, Dong-A University College of Medicine, Busan, Korea. wjeye@dau.ac.kr |
| 당뇨황반부종의 치료로서 덱사메타손 및 베바시주맙 주입 시 미세혈관류 회전율의 변화 |
|
김선태⋅정우진 |
|
동아대학교 의과대학 안과학교실 |
Correspondence:
Woo Jin Jeong,
Email: wjeye@dau.ac.kr
|
|
Received: 26 October 2017 • Revised: 4 January 2018 • Accepted: 25 March 2018 |
| Abstract |
PURPOSE
To evaluate microaneurysm (MA) turnover and changes in central retinal thickness after intravitreal dexamethasone implantation or intravitreal bevacizumab injection to treat diabetic macular edema. METHODS: Sixty eyes with diabetic macular edema were evaluated. In all, 30 eyes received intravitreal dexamethasone implants (group A) and 30 received bevacizumab injections (group B). All patients were followed-up at 3 and 6 months. MA formation, disappearance, and turnover (MA formation rate minus disappearance rate) were evaluated. When the disappearance rate was greater than the formation rate (so the turnover was ≤0), the microaneurysms were considered to have resolved. Central retinal thickness (CRT) was measured using optical coherence tomography at all visits. RESULTS: In group A, MA turnover was 86.6% at 3 months and 53.3% at 6 months, and thus decreased slightly over time, but was not eliminated. In group B, MA turnover was 56.6% at 3 months and 13.3% at 6 months; the between-group difference was statistically significant (p = 0.014). CRT decreased in both groups, but significantly less so in group B 3 months after injection. However, no significant between-group difference was apparent 6 months after injection. CONCLUSIONS: There were no significant between-group differences in either CRT or MA turnover 3 months after injection. However, at 6 months, dexamethasone implantation showed slightly better results than intravitreal bevacizumab injection. However, further research on long-term MA turnover is required. |
| Key Words:
Bevacizumab;Central macular thickness;Dexamethasone;Microaneurysm turnover;Microaneurysm |
|
PDF Links
Full text via DOI
Download Citation
