J Korean Ophthalmol Soc > Volume 57(6); 2016 > Article
Journal of the Korean Ophthalmological Society 2016;57(6):917-923.
DOI: https://doi.org/10.3341/jkos.2016.57.6.917    Published online June 15, 2016.
Retinal Vascular Caliber Changes in Diabetic Retinopathy after Panretinal Photocoagulation and Additive Bevacizumab Injections.
Ji Hyoung Chey, Jung Min Park
Department of Ophthalmology, Maryknoll Medical Center, Busan, Korea. pjm1438@hanmail.net
당뇨망막병증에서 범망막광응고술과 추가적 베바시주맙 주입술이 망막혈관 직경에 미치는 영향
최지형⋅박정민
메리놀병원 안과
Correspondence:  Jung Min Park,
Email: pjm1438@hanmail.net
Received: 18 February 2016   • Revised: 8 April 2016   • Accepted: 18 May 2016
Abstract
PURPOSE
To evaluate the effect of panretinal photocoagulation and additive intravitreal bevacizumab injections on central retinal vessel diameters and characteristic retinal vascular caliber changes in diabetic retinopathy. METHODS: Changes in central retinal vessel diameters were retrospectively analyzed before and 6 months after panretinal photocoagulation with or without additive intravitreal bevacizumab injections in 64 eyes first diagnosed with diabetic retinopathy. Vessel diameters and arteriovenous ratio (AVR) were measured using Interactive Vessel Analysis (IVAN) software and the Big six formula. RESULTS: There were significant decreases in central retinal artery equivalent (CRAE) and central retinal vein equivalent (CRVE) in both groups, with and without additive intravitreal bevacizumab injections, 6 months after completion of panretinal photocoagulation (p < 0.001, p = 0.008), but no significant change in AVR (p = 0.338). Additive intravitreal bevacizumab injections did not produce significant changes in central retinal vessel diameters after 6 months compared to vessel diameters treated with panretinal photocoagulation only. Retinal vascular caliber of progressed diabetic retinopathy showed smaller CRAE, larger CRVE, and smaller AVR compared to those of normal or diabetic Korean subjects in a previous study and showed no significant association with age. CONCLUSIONS: CRAE and CRVE decreased significantly 6 months after panretinal photocoagulation in diabetic retinopathy, but additive intravitreal bevacizumab injections did not cause significant additive changes to central retinal vascular calibers in this study. We established the standard retinal vascular caliber of Korean subjects in diabetic retinopathy and analyzed the effects of retinopathy on retinal vessel caliber.
Key Words: Bevacizumab;Diabetic retinopathy;Panretinal photocoagulation;Retinal vascular caliber


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