J Korean Ophthalmol Soc > Volume 57(5); 2016 > Article
Journal of the Korean Ophthalmological Society 2016;57(5):786-793.
DOI: https://doi.org/10.3341/jkos.2016.57.5.786    Published online May 15, 2016.
The Repeatability of Retinal Layer Thickness Measurements with Spectral-Domain Optical Coherence Tomography in Normal Eyes.
Min Seok Kang, Seung Young Yu, Hyung Woo Kwak
Department of Ophthalmology, Kyung Hee University Hospital, Kyung Hee University School of Medicine, Seoul, Korea. syyu@khu.ac.kr
스펙트럼영역 빛간섭단층촬영기를 이용한 정상인의 망막층별 두께 측정치의 반복성
강민석⋅유승영⋅곽형우
경희대학교 의학전문대학원 경희대학교병원 안과학교실
Received: 5 November 2015   • Revised: 21 April 2016   • Accepted: 22 April 2016
Abstract
PURPOSE
To evaluate the repeatability of retinal layer thickness measurements in normal eyes imaged using spectral domain optical coherence tomography (SD-OCT). METHODS: Sixty-eight eyes of 34 healthy subjects were enrolled in this study. Imaging was performed 4 times using 9 × 9 mm macular scans with SD-OCT (RS 3000 Advance HD OCT, NIDEK, Gamagori, Japan) at the same visit by an experienced examiner. After automatic retinal segmentation (layering) in 5 layers, the thickness of each layer was calculated. Macular thickness of 9 Early Treatment of Diabetic Retinopathy Study (ETDRS)-like regions was obtained. Repeatability for each of the 9 subfield areas was calculated by their repeatability coefficients and intraclass correlation coefficients (ICCs). RESULTS: There was no significant difference in average retinal thickness and each retinal layer thickness between all measurements acquired by the experienced examiner. The ICCs of retinal layer thickness ranged from 0.826 to 0.847 for the ganglion cell layer + inner plexiform layer, inner nuclear layer + outer plexiform layer and outer nuclear layer + external limiting membrane in the fovea. The ICCs were greater than 0.909 for the other intra-retinal layers in all 9 ETDRS subfield thickness between all measurement pairs. CONCLUSIONS: Excellent repeatability was observed for SD-OCT retinal segmented layer thickness measurements in healthy subjects.
Key Words: Automated segmentation;Intraclass correlation coefficients;Repeatability;Retinal layer thickness;Spectral domain optical coherence tomography


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