J Korean Ophthalmol Soc > Volume 57(2); 2016 > Article
Journal of the Korean Ophthalmological Society 2016;57(2):283-289.
DOI: https://doi.org/10.3341/jkos.2016.57.2.283    Published online February 1, 2016.
Mycophenolate Mofetil for Chronic Uveitis in Koreans.
Min Won Ahn, Hyun Woong Kim, Ji Eun Lee
1Department of Ophthalmology, Pusan National University Hospital, Busan, Korea. jlee@pusan.ac.kr
2Department of Ophthalmology, Busan Paik Hospital, Inje University College of Medicine, Busan, Korea.
3Department of Ophthalmology, Pusan National University School of Medicine, Busan, Korea.
한국인 만성 포도막염 환자에서 Mycophenolate Mofetil
안민원1⋅김현웅2⋅이지은1,3
부산대학교병원 안과1, 인제대학교 의과대학 부산백병원 안과학교실2, 부산대학교 의학전문대학원 안과학교실3
Abstract
PURPOSE
To evaluate the therapeutic effect and safety of mycophenolate mofetil (MMF) on chronic uveitis in Korean patients. METHODS: This study included 25 patients with chronic uveitis who used MMF and were followed up more than 6 months in 2 referral centers from 2010 to 2014. The medical records were analyzed retrospectively. The therapeutic effect was assessed based on control of inflammation, corticosteroid sparing effects, and discontinuation of MMF, and the safety was assessed based on side effects. Control of inflammation was defined as no active inflammation observed on at least 2 consecutive visits 28 days apart or more. RESULTS: The 25 patients consisted of 18 males and 7 females. The mean age of the patients was 47.52 years. The etiology of uveitis was as follows: Behcet's disease in 15 patients (60%), Vogt-Koyanagi-Harada disease in 4 (16%), sympathetic ophthalmia in 2 (8%), systemic lupus erythematosus in 1 (4%), and idiopathic uveitis in 3 (12%). Anatomic classification was anterior uveitis in 20% and posterior uveitis or panuveitis in 80% of patients. Complete control of inflammation was achieved in 44% and 50% of patients within 6 months and 1 year, respectively. Systemic corticosteroid dosage was reduced to 10 mg of prednisone or less while maintaining sustained control of inflammation in 36% and 45% of patients for 6 months and 1 year, respectively. MMF was discontinued in 3 patients (12%) due to side effects and in 2 patients (8%) due to lack of effectiveness. CONCLUSIONS: MMF was effective and side effects were uncommon when managing chronic uveitis in Korean patients.
Key Words: Chronic uveitis;Mycophenolate mofetil


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