J Korean Ophthalmol Soc > Volume 55(3); 2014 > Article
Journal of the Korean Ophthalmological Society 2014;55(3):437-442.
DOI: https://doi.org/10.3341/jkos.2014.55.3.437    Published online March 15, 2014.
A Case of Autologous Tragal Perichondrium Graft in a Patient with Mooren's Ulcer.
Dong Ik Lee, Kyoung Woo Kim, Jae Chan Kim
Department of Ophthalmology, Chung-Ang University College of Medicine, Seoul, Korea. jck50ey@kornet.net
무렌각막궤양 환자에서 시행한 자가 귀구슬 연골막 이식술 1예
Department of Ophthalmology, Chung-Ang University College of Medicine, Seoul, Korea
To report the effectiveness of an autologous tragal perichondrium graft for an active Mooren's ulcer. CASE SUMMARY: A 49-year-old male was referred to our clinic with Mooren's ulcer in his left eye. On the first visit, the ulcer involved the entire 360 degrees of the peripheral cornea and the visual acuity was 0.04. As the ulcer did not respond to medical treatment and progressed rapidly, the authors decided on surgical treatment. First, the involved cornea and nearby conjunctiva were removed and the defect was successfully reconstructed with autologous tragal perichondrium and allogenic limbal graft. The progression of corneal ulceration ceased after surgery and the patient's symptoms remarkably improved. Additionally, the graft showed rapid vascularization and engraftment within a week. However, as the opacity evolved and progressed to the central cornea, penetrating keratoplasty (PKP) was performed 5 months after the perichondrial graft. There was no rejection and corneal translucency was kept clear with low-dose steroid eye drops until 6 months after PKP without any sign of limbal deficiency. The patient's final best corrected visual acuity was 0.125. CONCLUSIONS: The present study shows that autologous tragal perichondrium graft is an effective method of treatment for active Mooren's ulcer by defect reconstruction and results in survival of the co-transplanted graft as well as maintaining corneal functions.
Key Words: Autologus tragal perichondrium graft;Mesenchymal stem cell;Mooren's ulcer

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